2022
The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines
Rezaeian A, Khatami F, Heidari Keshel S, Akbari M, Mirzaei A, Gholami K, Mohammadi Farsani R, Aghamir S. The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines. Scientific Reports 2022, 12: 20924. PMID: 36463254, PMCID: PMC9719468, DOI: 10.1038/s41598-022-23204-x.Peer-Reviewed Original ResearchConceptsExpression of epithelial to mesenchymal transitionCancer cell linesProstate cancerMesenchymal stem cells-derived exosomesCell linesCells-derived exosomesHormone-refractory prostate cancerMSC-exosomesKidney cancer cell linesPercentage of apoptotic cellsProliferation of cancer cellsDecreased Bcl2 expressionEpithelial to mesenchymal transitionAnti-angiogenic effectsRenal cancer cell linesGene expression changesRealtime PCR methodKidney tumor cell lineOsteopontin variantsTumor cell linesVEGF-CAntitumor effectBladder cancerHormone-sensitiveRenal cancer
2021
The importance of personalized medicine in urological cancers
Khatami F, Hassanzad M, Nikfar S, Guitynavard F, Karimaee S, Tamehri Zadeh S, Gholami K, Rezaeian A, Feiz-Abadi S, Jahanshahi F, Aghamir S. The importance of personalized medicine in urological cancers. Journal Of Diabetes & Metabolic Disorders 2021, 21: 841-852. PMID: 35673449, PMCID: PMC9167380, DOI: 10.1007/s40200-021-00824-0.Peer-Reviewed Original ResearchAndrogen deprivation therapyExcision repair cross-complementing group 1Prostate cancerAndrogen receptorUrological cancersResistance to androgen deprivation therapyPersonalized medicineAssociated with metastatic potentialAdvanced prostate cancerMetastatic bladder cancerPersonalized therapeutic regimensDNA-damaging chemotherapyDeprivation therapyAndrogen independenceMuscle-invasiveTargeted therapyTherapeutic regimensBladder cancerPoor prognosisMetastatic potentialTumor developmentGroup 1PTEN geneMolecular profilingCancer