2024
Acute Stroke Treatment: Thrombectomy
Veltri N, Elnazer S, De Havenon A. Acute Stroke Treatment: Thrombectomy. 2024, 93-102. DOI: 10.1007/978-3-031-66289-8_9.Peer-Reviewed Original ResearchPrediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research.
de Havenon A, Ayodele I, Alhanti B, Mac Grory B, Xian Y, Fonarow G, Smith E, Worrall B. Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research. Neurology 2024, 102: e209424. PMID: 38759133, PMCID: PMC11175650, DOI: 10.1212/wnl.0000000000209424.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionNIH Stroke ScaleConsistent with previous studiesAdult acute ischemic stroke patientsCross-sectional cohort analysisAcute ischemic stroke patientsLarge vessel occlusion strokePosterior circulation strokeDiagnosis of ischemic strokeReceiver operating curveNeuroimagingGWTG-StrokeIschemic stroke patientsVascular neuroimagingAdult patientsAtrial fibrillationCirculation strokeCohort analysisClinical covariatesStroke patientsOcclusion strokeVessel occlusionPrevious studiesCut-pointsStroke ScaleCost-benefit analysis of intraoperative neuromonitoring for cardiac surgery
Jain B, Rahim F, Thirumala P, McGarvey M, Balzer J, Nogueira R, van der Goes D, de Havenon A, Sultan I, Ney J. Cost-benefit analysis of intraoperative neuromonitoring for cardiac surgery. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107576. PMID: 38232584, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107576.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionCardiac surgeryIntraoperative neuromonitoringModified Rankin ScaleDetect large vessel occlusionHigh-risk patientsOne-way sensitivity analysesLifetime costsProbabilistic sensitivity analysesNeurological complicationsRankin ScaleSurgeryFunctional outcomesLifetime horizonVessel occlusionPatientsDecision-analysis treeSocietal perspectiveNeuromonitoringCost-saving
2023
ASPECTS evolution after endovascular successful reperfusion in the early and extended time window.
Anadani M, Finitsis S, Pop R, Darcourt J, Clarençon F, Richard S, de Havenon A, Liebeskind D, Marnat G, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Blanc R, Lapergue B, Consoli A, Eugène F, Vannier S, Caroff J, Denier C, Boulanger M, Gauberti M, Saleme S, Macian F, Rosso C, Turc G, Ozkul-Wermester O, Papagiannaki C, Olivot J, Le Bras A, Evain S, Wolff V, Timsit S, Gentric J, Bourdain F, Veunac L, Maïer B, Ben Hassen W, Gory B. ASPECTS evolution after endovascular successful reperfusion in the early and extended time window. Interventional Neuroradiology 2023, 15910199231196953. PMID: 37671452, DOI: 10.1177/15910199231196953.Peer-Reviewed Original ResearchSuccessful reperfusionEndovascular therapySafety outcomesAlberta Stroke Program Early CTAnterior circulation large vessel occlusionEarly neurological improvementProspective multicenter registrySuccessful endovascular therapyLarge vessel occlusionExtended time windowIncomplete reperfusionEarly CTMulticenter registryNeurological improvementStroke severityComplete reperfusionParenchymal hemorrhageStroke patientsExcellent outcomesInfarct extentVessel occlusionFavorable outcomeGood collateralsReliable imaging biomarkerReperfusionLow‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury
Sujijantarat N, Koo A, Jambor I, Malhotra A, Mazurek M, Parasuram N, Yadlapalli V, Chavva I, Lalwani D, Zabinska J, Roy J, Antonios J, Elsamadicy A, Renedo D, Hebert R, Schindler J, Gilmore E, Sansing L, de Havenon A, Olexa M, Schiff S, Iglesias J, Rosen M, Kimberly W, Petersen N, Sheth K, Matouk C. Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.000921.Peer-Reviewed Original ResearchMechanical thrombectomyInterventional radiology suiteMagnetic resonance imagingRadiology suiteConventional MRIResonance imagingCerebral Infarction scoreOngoing brain injuryLarge vessel occlusionInfarct burdenRevascularization timeInfarct volumeClinical characteristicsInfarct progressionAdverse eventsIschemic changesMethods PatientsMedian timeBedside evaluationBrain injuryTimely imagingResults TwentyPatientsSubsequent imagingProcedural detailsRESCUE‐ICAS: Rationale and Study Design
Almallouhi E, de Havenon A, Asi K, Limaye K, Maier I, Starke R, Psychogios M, Inoa V, Grossberg J, Mascitelli J, Samaniego E, Fragata I, Kass‐Hout T, Capasso F, Dmytriw A, Jehani H, Modovan K, Yaghi S, Ezzeldin M, Grandhi R, Wolfe S, Fargen K, Jabbour P, Naamani K, Spiotta A, Zaidat O, Kasab S. RESCUE‐ICAS: Rationale and Study Design. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.122.000530.Peer-Reviewed Original ResearchICAS-LVORescue therapyIntracranial stenosisCerebral Infarction scoreMechanical thrombectomy failureSymptomatic intracranial hemorrhageProspective cohort studyLarge vessel occlusionRankin Scale scoreOptimal treatment strategyThrombectomy failureProspective registrySuccessful recanalizationCohort studyModified thrombolysisAtherosclerotic diseaseIntracranial hemorrhageTreatment strategiesCommon causeInclusion criteriaRadiographic dataImaging variablesScale scoreMT casesPatients
2022
Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee
Nguyen T, Castonguay A, Siegler J, Nagel S, Lansberg M, de Havenon A, Sheth S, Abdalkader M, Tsai J, Albers G, Masoud H, Jovin T, Martins S, Nogueira R, Zaidat O, Committee F. Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee. Stroke Vascular And Interventional Neurology 2022, 3 PMID: 39380893, PMCID: PMC11460660, DOI: 10.1161/svin.122.000512.Peer-Reviewed Original ResearchSociety of VascularLarge vessel occlusion strokeLarge vessel occlusionNeurology guidelinesExtended time windowOcclusion strokeEndovascular therapyVessel occlusionAnterior circulation large vessel occlusion strokeClinical-imaging mismatchDEFUSE 3 studyComputed tomography perfusionRecent clinical trialsTreatment of patientsNew treatment paradigmSole imaging modalityMagnetic resonance imagingWriting groupMechanical thrombectomyEndovascular treatmentPatient selectionInfarct sizeLate presentationTomography perfusionTreatment paradigmRescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis
Almallouhi E, Murad M, Chalhoub R, Kicielinski K, Lena J, Brennan E, Zaidat O, de Havenon A, Spiotta A, Al Kasab S. Rescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2022, 3 DOI: 10.1161/svin.122.000510.Peer-Reviewed Original ResearchLarge vessel occlusionEmbolic large-vessel occlusionRescue therapyICAS-LVOOutcomes of patientsVessel occlusionIntracranial atherosclerosisRescue treatmentOdds ratioSystematic reviewEmergent large vessel occlusionRescue endovascular treatmentRandom-effects modelAcute strokeBackground PatientsSuccessful recanalizationMechanical thrombectomyEndovascular treatmentBetter outcomesPatientsMeta-AnalysisCINAHL CompleteCombination of treatmentsOcclusionDatabase date2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee
Masoud H, de Havenon A, Castonguay A, Asif K, Nguyen T, Mehta B, Abdalkader M, Gutierrez S, Leslie‐Mazwi T, Mansour O, Ma A, Czap A, Kenmuir C, Sheth S, Novakovic‐White R, Nour M, Jadhav A, Janardhan V, Hassan A, Liebeskind D, Malik A, Zaidat O. 2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000276.Peer-Reviewed Original ResearchSociety of VascularAcute ischemic strokeLarge vessel occlusionIntravenous thrombolysisNeurology guidelinesPractice UpdateIschemic strokeMechanical thrombectomyVessel occlusionClinical trialsLarge vessel occlusion acute ischemic strokeEmergent large vessel occlusionIschemic stroke patientsRecent clinical trialsClass of recommendationRecent clinical dataClinical trial resultsLevel of evidenceClinical trial dataClinical decision makingStroke patientsCombination therapyClinical dataThrombolysisCurrent evidence
2021
Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial
Yaghi S, Raz E, Dehkharghani S, Riina H, McTaggart R, Jayaraman M, Prabhakaran S, Liebeskind DS, Khatri P, Mac Grory B, Al-Mufti F, Lansberg M, Albers G, de Havenon A. Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial. Stroke 2021, 52: 2690-2693. PMID: 34157865, DOI: 10.1161/strokeaha.120.033806.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsLarge vessel occlusionPenumbral tissueVessel occlusionMismatch volumeAcute large vessel occlusionAnterior circulation occlusionEndovascular thrombectomy patientsAcute ischemic strokePost Hoc AnalysisReperfusion statusThrombectomy patientsTICI 0Cerebral infarctionEndovascular thrombectomyIschemic strokeUntreated patientsPrimary outcomeSalvageable tissueTreatment modalitiesHoc AnalysisPerfusion timePatientsNatural historyOcclusionPrediction of Infarct Volume at the 24 Hours after Late Window Presentation with Perfusion Imaging in Patients with Anterior Circulation Large Vessel Occlusion (2463)
Agarwal S, Raz E, Dehkharghani S, Christensen S, Lansberg M, Yaghi S, de Havenon A. Prediction of Infarct Volume at the 24 Hours after Late Window Presentation with Perfusion Imaging in Patients with Anterior Circulation Large Vessel Occlusion (2463). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2463.Peer-Reviewed Original ResearchPredicting neuroimaging eligibility for extended-window endovascular thrombectomy.
de Havenon A, Mickolio K, O'Donnell S, Stoddard G, McNally JS, Alexander M, Taussky P, Awad AW. Predicting neuroimaging eligibility for extended-window endovascular thrombectomy. Journal Of Neurosurgery 2021, 135: 1100-1104. PMID: 33636705, PMCID: PMC8387497, DOI: 10.3171/2020.8.jns20386.Peer-Reviewed Original ResearchLarge vessel occlusionAlberta Stroke Program Early CT ScoreTissue plasminogen activatorEndovascular thrombectomyC-statisticPatients 5Stroke patientsTreatment windowFurther patient careHealth Stroke ScaleIschemic stroke treatmentLarge patient registriesSecond outcomePatients 4.5Stroke ScaleAdvanced imaging toolsStroke treatmentSalvageable penumbraCT scorePatient eligibilityClinical variablesPatient RegistryMultivariable modelMR perfusionTreatment cutoffDuration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke
de Havenon A, Alexander MD, Nogueira RG, Haussen DC, Castonguay AC, Linfante I, Johnson MA, Nguyen TN, Mokin M, Zaidat OO. Duration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke. Journal Of NeuroInterventional Surgery 2021, 13: 1128-1131. PMID: 33526478, PMCID: PMC8325713, DOI: 10.1136/neurintsurg-2020-016961.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke patientsIschemic stroke patientsSymptomatic strokeSuccessful reperfusionLogistic regression modelsAcute strokeEndovascular therapyStroke patientsLarge vessel occlusive strokeAnterior circulation occlusionCerebral Infarction scoreReal-world cohortLarge vessel occlusionBalloon guide catheterMiddle cerebral arteryIndividual patient dataInternal carotid arteryProbability of reperfusionLower ratesOcclusive strokeEndovascular thrombectomyMechanical thrombectomySecondary outcomesStroke onsetPrimary outcome
2020
The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105380. PMID: 33166769, PMCID: PMC7736545, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105380.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsBaseline glucose levelsInfarct growthGlucose levelsPrimary outcomeAcute ischemic stroke patientsAggressive glycemic controlDEFUSE 3 patientsIschemic core volumePotential neuroprotective benefitsIschemic stroke patientsGood functional outcomeLarge vessel occlusionEffects of hyperglycemiaSuccessful endovascular reperfusionAdmission glucoseInfarction growthEndovascular reperfusionSuccessful reperfusionTICI 2bIschemic strokeNeuroprotective benefitsEndovascular therapyGlycemic controlStroke patients
2019
Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study
Anadani M, Arthur AS, Alawieh A, Orabi Y, Alexandrov A, Goyal N, Psychogios MN, Maier I, Kim JT, Keyrouz SG, de Havenon A, Petersen NH, Pandhi A, Swisher CB, Inamullah O, Liman J, Kodali S, Giles JA, Allen M, Wolfe SQ, Tsivgoulis G, Cagle BA, Oravec CS, Gory B, De Marini P, Kan P, Rahman S, Richard S, Nascimento FA, Spiotta A. Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study. Journal Of NeuroInterventional Surgery 2019, 12: 932-936. PMID: 31806668, PMCID: PMC7998040, DOI: 10.1136/neurintsurg-2019-015561.Peer-Reviewed Original ResearchConceptsSBP reductionSystolic blood pressureSuccessful reperfusionMechanical thrombectomyPoor outcomeSafety outcomesAnterior circulation large vessel occlusionElevated systolic blood pressureModified Rankin Scale scoreBlood pressure reductionComprehensive stroke centerSymptomatic intracerebral hemorrhageAcute ischemic strokeMulticenter retrospective studyRankin Scale scoreLarge vessel occlusionIncomplete reperfusionReperfusion statusSafety endpointIschemic strokeStroke centersBlood pressureComplete reperfusionEndovascular therapyIntracerebral hemorrhageResults From DEFUSE 3
de Havenon A, Mlynash M, Kim-Tenser MA, Lansberg MG, Leslie-Mazwi T, Christensen S, McTaggart RA, Alexander M, Albers G, Broderick J, Marks MP, Heit JJ, Investigators O. Results From DEFUSE 3. Stroke 2019, 50: 632-638. PMID: 30726184, PMCID: PMC6628906, DOI: 10.1161/strokeaha.118.023407.Peer-Reviewed Original ResearchConceptsIschemic core volumeLarge vessel occlusionEndovascular thrombectomyCollateral statusTomography angiographyFunctional independenceDEFUSE 3Poor collateralsLeptomeningeal collateralsStroke patientsVessel occlusionGood collateralsAnterior circulation large vessel occlusionBaseline ischemic core volumeSmall ischemic core volumeAcute ischemic stroke patientsDEFUSE 3 patientsIschemic stroke patientsModified Rankin ScaleStroke-related deathComputed tomography angiographyGood leptomeningeal collateralsTreatment effectsNeurological outcomePrespecified analysis
2017
Advanced imaging in acute ischemic stroke.
Kilburg C, Scott McNally J, de Havenon A, Taussky P, Kalani MY, Park MS. Advanced imaging in acute ischemic stroke. Neurosurgical FOCUS 2017, 42: e10. PMID: 28366054, DOI: 10.3171/2017.1.focus16503.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeLarge vessel occlusionTranscranial Doppler ultrasonographyCT angiographyVessel wall MRIMR angiographyIschemic strokeDoppler ultrasonographyVessel occlusionMRI techniquesCollateral blood flowImaging modalitiesConventional CTCharacteristics of lesionsFour-dimensional CT angiographyClot burdenCryptogenic strokeAcute settingStroke treatmentPatent foramenOccult lesionsInvasive alternativeBlood flowNew imaging modalityNatural history