SH2 domain protein E and ABL signaling regulate blood vessel size
Schumacher J, Wright Z, Florat D, Anand S, Dasyani M, Batta S, Laverde V, Ferrari K, Klimkaite L, Bredemeier N, Gurung S, Koller G, Aguera K, Chadwick G, Johnson R, Davis G, Sumanas S. SH2 domain protein E and ABL signaling regulate blood vessel size. PLOS Genetics 2024, 20: e1010851. PMID: 38190417, PMCID: PMC10798624, DOI: 10.1371/journal.pgen.1010851.Peer-Reviewed Original ResearchZebrafish embryosDorsal aortaSrc homology 2 domainMutant phenotypeVascular tubulogenesisCell numberNegative regulatorBiological roleMolecular mechanismsProtein EChemical inhibitionUmbilical vein cellsE proteinEndothelial cell proliferationHuman endothelial cell culturesCell proliferationVein cellsProteinMutantsVascular tubesSpecific overexpressionTubulogenesisEndothelial cell culturesTight junctionsABL