2019
In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task
Carr ZJ, Miller L, Ruiz-Velasco V, Kunselman AR, Karamchandani K. In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task. Journal Of Neuroimmune Pharmacology 2019, 14: 383-390. PMID: 31119596, DOI: 10.1007/s11481-019-09857-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsAppetitive BehaviorAttentionDeliriumDisease Models, AnimalDrug Evaluation, PreclinicalExecutive FunctionFemaleFrontal LobeHydrocortisoneInflammationLipopolysaccharidesQuetiapine FumarateRandom AllocationRatsRats, Sprague-DawleyReversal LearningRewardSet, PsychologyTumor Necrosis Factor-alphaConceptsCortisol levelsTumor necrosis factor-alpha levelsNecrosis factor-alpha levelsSprague-Dawley female ratsBeneficial effectsModel of neuroinflammationTreatment of deliriumTNF-α levelsAtypical antipsychotic medicationsEffects of quetiapineDawley female ratsIntraperitoneal placeboPlacebo groupQuetiapine groupNeuroinflammatory modelReversal learningAntipsychotic medicationPre-clinical validationCortisol secretionSerum cortisolFemale ratsPlaceboCortisol productionRodent modelsQuetiapine
2018
Gender differences in the use of atypical antipsychotic medications for ICU delirium
Karamchandani K, Schoaps RS, Printz J, Kowaleski JM, Carr ZJ. Gender differences in the use of atypical antipsychotic medications for ICU delirium. Critical Care 2018, 22: 220. PMID: 30236134, PMCID: PMC6148964, DOI: 10.1186/s13054-018-2143-5.Peer-Reviewed Original Research