2004
Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews P, Cowen P. Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor. American Journal Of Psychiatry 2004, 161: 368-370. PMID: 14754790, DOI: 10.1176/appi.ajp.161.2.368.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA concentrationsAcute administrationGABA concentrationSelective serotonin reuptake inhibitor citalopramSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitor citalopramCortical gamma-aminobutyric acidActions of SSRIsGABA/creatine ratiosReuptake inhibitor citalopramSerotonin reuptake inhibitorsGABA neuronsSSRI treatmentReuptake inhibitorsIntravenous citalopramDepressed patientsCreatine ratioHealthy volunteersCortical levelOccipital cortexCrossover designMean increaseMagnetic resonance spectroscopyMood improvement
2003
GABA and mood disorders
TAYLOR M, BHAGWAGAR Z, COWEN P, SHARP T. GABA and mood disorders. Psychological Medicine 2003, 33: 387-393. PMID: 12701660, DOI: 10.1017/s0033291702006876.Peer-Reviewed Original ResearchMeSH KeywordsBrainGamma-Aminobutyric AcidHumansLimbic SystemMagnetic Resonance SpectroscopyMood DisordersRaphe NucleiReceptors, GABA-ASerotoninSerotonin Agents