2005
P.2.01 The effects of altering dietary L-tryptophan on the performance of an iterated Prisoner's Dilemma (PD) game in healthy volunteers
Wood R, Rilling J, Sanfey A, Bhagwagar Z, Rogers R. P.2.01 The effects of altering dietary L-tryptophan on the performance of an iterated Prisoner's Dilemma (PD) game in healthy volunteers. European Neuropsychopharmacology 2005, 15: s32. DOI: 10.1016/s0924-977x(05)80141-5.Peer-Reviewed Original Research
2004
Preferential 5-HT1A Autoreceptor Occupancy by Pindolol is Attenuated in Depressed Patients: Effect of Treatment or an Endophenotype of Depression?
Rabiner E, Bhagwagar Z, Gunn R, Cowen P, Grasby P. Preferential 5-HT1A Autoreceptor Occupancy by Pindolol is Attenuated in Depressed Patients: Effect of Treatment or an Endophenotype of Depression? Neuropsychopharmacology 2004, 29: 1688-1698. PMID: 15127080, DOI: 10.1038/sj.npp.1300472.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAdultAutoreceptorsDepressive DisorderDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedPhenotypePindololPiperazinesPsychiatric Status Rating ScalesPyridinesRadiopharmaceuticalsReceptor, Serotonin, 5-HT1ASerotonin AntagonistsTomography, Emission-ComputedIncreased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews P, Cowen P. Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor. American Journal Of Psychiatry 2004, 161: 368-370. PMID: 14754790, DOI: 10.1176/appi.ajp.161.2.368.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA concentrationsAcute administrationGABA concentrationSelective serotonin reuptake inhibitor citalopramSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitor citalopramCortical gamma-aminobutyric acidActions of SSRIsGABA/creatine ratiosReuptake inhibitor citalopramSerotonin reuptake inhibitorsGABA neuronsSSRI treatmentReuptake inhibitorsIntravenous citalopramDepressed patientsCreatine ratioHealthy volunteersCortical levelOccipital cortexCrossover designMean increaseMagnetic resonance spectroscopyMood improvementEffects of beta-adrenoceptor blockade on components of human decision-making
Rogers R, Lancaster M, Wakeley J, Bhagwagar Z. Effects of beta-adrenoceptor blockade on components of human decision-making. Psychopharmacology 2004, 172: 157-164. PMID: 14716472, DOI: 10.1007/s00213-003-1641-5.Peer-Reviewed Original ResearchConceptsProbabilistic rewardsCortico-limbic systemsBrain imaging studiesSeries of choicesOrbitofrontal cortexEmotional aspectsSubjective stateSubjects designPunishment signalsCingulate cortexNegative ratingsProbability of losingNeurological patientsSubjective changesHealthy volunteersMoodRewardBeta-adrenoceptor blockadeCatecholamine systemsBeta-adrenoceptor blockersVisual analog scaleImaging studiesSlower heart rateCortexConclusionsThese results
2003
Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635
Bhagwagar Z, Montgomery A, Grasby P, Cowen P. Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635. Biological Psychiatry 2003, 54: 890-895. PMID: 14573316, DOI: 10.1016/s0006-3223(03)00466-9.Peer-Reviewed Original ResearchConceptsReceptor BPMajor depressionPositron emission tomographySerotonin-1A receptor bindingEmission tomographyPositron emission tomography scanAcute major depressionEmission tomography scanCertain brain areasElevated cortisol levelsLack of effectCortisol hypersecretionAcute administrationSingle doseHydrocortisone treatmentDepressed patientsTomography scanHealthy volunteersBrain areasCrossover designCortisol levelsSerotonin1A receptorsMale subjectsFemale subjectsPatientsRisperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients.
Sharpley A, Bhagwagar Z, Hafizi S, Whale W, Gijsman H, Cowen P. Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients. The Journal Of Clinical Psychiatry 2003, 64: 192-6. PMID: 12633128, DOI: 10.4088/jcp.v64n0212.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAntidepressive AgentsAntipsychotic AgentsCross-Over StudiesDepressive DisorderDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedPersonality InventoryPlacebosPolysomnographyPsychiatric Status Rating ScalesRisperidoneSleep, REMTreatment OutcomeWakefulnessConceptsRapid eye movement (REM) sleepEye movement sleepDepressed patientsHealthy volunteersRisperidone treatmentMovement sleepREM sleepMedication-resistant depressed patientsTreatment-resistant depressed patientsConventional antidepressant medicationAntidepressant-like effectsAntipsychotic agent risperidoneDepression Rating ScaleMajor depressive disorderDSM-IV criteriaPatients meritRisperidone additionRisperidone augmentationAntidepressant medicationRisperidone administrationSingle doseTherapeutic dosesAugmentation agentsDepressive disorderHealthy subjects
2002
Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients
Bhagwagar Z, Hafizi S, Cowen P. Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients. Journal Of Affective Disorders 2002, 72: 249-255. PMID: 12450642, DOI: 10.1016/s0165-0327(01)00467-0.Peer-Reviewed Original ResearchConceptsGrowth hormone releaseDepressed patientsMajor depressionHormone releaseStress-induced cortisol secretionBrain serotonin functionPlasma GH levelsEffects of cortisolEffect of hydrocortisoneCross-over designStressful life eventsGH responseGH levelsSingle doseCortisol secretionGH releaseHealthy controlsSerotonin functionRecurrent depressionTRP infusionHealthy volunteersCortisol modulationDepressive symptomatologyDepressed subjectsEuthymic subjectsAcute citalopram administration produces correlated increases in plasma and salivary cortisol
Bhagwagar Z, Hafizi S, Cowen P. Acute citalopram administration produces correlated increases in plasma and salivary cortisol. Psychopharmacology 2002, 163: 118-120. PMID: 12185409, DOI: 10.1007/s00213-002-1149-4.Peer-Reviewed Original ResearchConceptsSalivary cortisol levelsCortisol levelsSelective serotonin re-uptake inhibitorsSalivary cortisolSerotonin re-uptake inhibitorsAcute citalopram administrationRe-uptake inhibitorsCross-over designSalivary cortisol concentrationsCitalopram administrationIntravenous administrationCortisol releaseHealthy volunteersCortisol concentrationsSaliva cortisolCitalopramCortisolParallel increaseAdministrationCorrelated increaseAcceptable meansTryptophan Depletion Alters the Decision-Making of Healthy Volunteers through Altered Processing of Reward Cues
Rogers R, Tunbridge E, Bhagwagar Z, Drevets W, Sahakian B, Carter C. Tryptophan Depletion Alters the Decision-Making of Healthy Volunteers through Altered Processing of Reward Cues. Neuropsychopharmacology 2002, 28: 153-162. PMID: 12496952, DOI: 10.1038/sj.npp.1300001.Peer-Reviewed Original ResearchConceptsAmino acid drinkReward cuesOrbitofrontal cortexNegative outcomesReduced discriminationAltered processingTryptophan depletionHuman choiceCuesMonoamine neurotransmitter systemsAltered discriminationNeurotransmitter systemsBiasesDiscriminationCortexGamblesProcessingPsychiatric illnessCognitionHealthy volunteersAnhedoniaMoodFunctioningPresent studyLittle evidence
2000
Modelling a loss event: effect of imagined bereavement on the hypothalamic–pituitary–adrenal axis
McCLEERY J, BHAGWAGAR Z, SMITH K, GOODWIN G, COWEN P. Modelling a loss event: effect of imagined bereavement on the hypothalamic–pituitary–adrenal axis. Psychological Medicine 2000, 30: 219-223. PMID: 10722192, DOI: 10.1017/s0033291799001361.Peer-Reviewed Original ResearchConceptsNegative mood induction procedureNegative mood inductionMood induction procedureMood inductionRelevant psychosocial stressorsIndividual differencesCortisol responseSalivary cortisol responseTransient moodPsychological stateInduction procedureAcute cortisol responsePsychosocial stressorsMood disorders researchDisorder researchCortisol outputStressorsBereavementNeuroendocrine responsesMoodAdrenal axisDepressive illnessHealthy volunteersMusicImportant mediator
1999
Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?
Whale R, Bhagwagar Z, Cowen P. Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors? Psychopharmacology 1999, 145: 223-226. PMID: 10463324, DOI: 10.1007/s002130051052.Peer-Reviewed Original ResearchConceptsPlasma growth hormoneGrowth hormoneCross-over design studyEffect of ketanserinGrowth hormone responsePathophysiology of depressionGrowth hormone releaseNeuroendocrine probeAntidepressant medicationHealthy menReceptor agonistReceptor subtypesHormone releaseHealthy volunteersBlood samplesNeuroendocrine profilePlasma prolactinAgonist activityHormone responseReceptor functionAssay of prolactinZolmitriptanHormoneOral temperatureMode of action