2003
Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients.
Sharpley A, Bhagwagar Z, Hafizi S, Whale W, Gijsman H, Cowen P. Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients. The Journal Of Clinical Psychiatry 2003, 64: 192-6. PMID: 12633128, DOI: 10.4088/jcp.v64n0212.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAntidepressive AgentsAntipsychotic AgentsCross-Over StudiesDepressive DisorderDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedPersonality InventoryPlacebosPolysomnographyPsychiatric Status Rating ScalesRisperidoneSleep, REMTreatment OutcomeWakefulnessConceptsRapid eye movement (REM) sleepEye movement sleepDepressed patientsHealthy volunteersRisperidone treatmentMovement sleepREM sleepMedication-resistant depressed patientsTreatment-resistant depressed patientsConventional antidepressant medicationAntidepressant-like effectsAntipsychotic agent risperidoneDepression Rating ScaleMajor depressive disorderDSM-IV criteriaPatients meritRisperidone additionRisperidone augmentationAntidepressant medicationRisperidone administrationSingle doseTherapeutic dosesAugmentation agentsDepressive disorderHealthy subjects
2001
Decreased sensitivity of 5-HT1D receptors in melancholic depression
Whale R, Clifford E, Bhagwagar Z, Cowen P. Decreased sensitivity of 5-HT1D receptors in melancholic depression. The British Journal Of Psychiatry 2001, 178: 454-457. PMID: 11331562, DOI: 10.1192/bjp.178.5.454.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGrowth hormone responseGrowth hormone releaseSSRI treatmentMajor depressionHormone releaseMelancholic depressionHormone responseBrain serotonin functionSerotonin reuptake inhibitorsReuptake inhibitorsDepressive syndromeReceptor agonistReceptor subtypesSerotonin functionHealthy subjectsReceptor sensitivityPatientsControl groupMarked reductionZolmitriptanDepressionReceptorsTreatmentSelective ligands