2012
Antidepressants
Bhagwagar Z, Heninger G. Antidepressants. 2012, 1185-1198. DOI: 10.1093/med/9780199696758.003.0153.Peer-Reviewed Original ResearchWorld Health Organization Global BurdenMajor public health problemPharmacology of antidepressantsLargest causeTreatment of depressionMajor depressive disorderPublic health problemAbstract Major depressive disorderImportance of depressionRecurrent illnessDepressive disorderPrimary treatmentAntidepressant drugsGlobal burdenHigh riskHealth problemsDepressionAntidepressantsDrugsPatientsDepressed individualsSelective useCliniciansBurdenDisease
2007
Bipolar disorder: the neglected psychosis
Bhagwagar Z, Goodwin G. Bipolar disorder: the neglected psychosis. Psychiatry 2007, 6: 389-392. DOI: 10.1016/j.mppsy.2007.06.005.Peer-Reviewed Original ResearchBipolar disorderAnti-manic actionMainstay of treatmentNon-pharmacological interventionsLong-term treatmentStage of illnessRole of intracellularBipolar depressionMonoaminergic transmissionDepressive episodeDrug treatmentEffective treatmentTherapeutic interventionsIllnessPatientsSignificant tollGold standardTreatmentEpisodesDisordersDepressionInterventionRelative lackAntipsychoticsPharmacotherapy
2005
Increased salivary cortisol after waking in depression
Bhagwagar Z, Hafizi S, Cowen P. Increased salivary cortisol after waking in depression. Psychopharmacology 2005, 182: 54-57. PMID: 15991000, DOI: 10.1007/s00213-005-0062-z.Peer-Reviewed Original ResearchConceptsSalivary cortisolMedication-free subjectsMorning cortisol secretionCommunity-based sampleExaggerated releaseCortisol secretionAcute depressionHealthy controlsMajor depressionCortisol levelsDepressed subjectsCortisolMore cortisolDepressionPatientsRecent studiesSubjectsHypersecretionPathophysiologyObjectiveToMinMethodsWeResultsInControlSecretion
2004
Inositol for depressive disorders
Taylor M, Wilder H, Bhagwagar Z, Geddes J. Inositol for depressive disorders. Cochrane Database Of Systematic Reviews 2004, 2004: cd004049. PMID: 15106232, PMCID: PMC6984679, DOI: 10.1002/14651858.cd004049.pub2.Peer-Reviewed Original ResearchConceptsTreatment of depressionCochrane Controlled Trials RegisterControlled Trials RegisterTrials RegisterAdjunctive therapyDepressive disorderNeurosis Controlled Trials RegisterCochrane Collaboration DepressionAcceptability of treatmentDouble-blind designShort-term trialsAntidepressant medicationDATA COLLECTIONTherapeutic benefitAlternative treatmentReference listsAffective disordersEffective interventionsTerm trialsAdverse effectsTrialsPoor acceptabilityDepressionTreatmentDisorders
2002
The role of lithium in the treatment of bipolar depression
Bhagwagar Z, Goodwin G. The role of lithium in the treatment of bipolar depression. Clinical Neuroscience Research 2002, 2: 222-227. DOI: 10.1016/s1566-2772(02)00046-4.Peer-Reviewed Original ResearchState and trait abnormalities in serotonin function in major depression
Bhagwagar Z, Whale R, Cowen P. State and trait abnormalities in serotonin function in major depression. The British Journal Of Psychiatry 2002, 180: 24-28. PMID: 11772847, DOI: 10.1192/bjp.180.1.24.Peer-Reviewed Original ResearchConceptsCortisol responseHealthy controlsMajor depressionSerotonin functionRecovered subjectsAdrenal axis dysfunctionBrain serotonin functionPlacebo-controlled designMarker of vulnerabilityAxis dysfunctionClinical recoveryReuptake inhibitorsUnmedicated subjectsProlactin responseDepressed patientsEndocrine responsesNeuroendocrine studiesDepressed subjectsCitalopramDepressionPatientsSubjectsResponseDysfunctionNeurotransmission
2001
Decreased sensitivity of 5-HT1D receptors in melancholic depression
Whale R, Clifford E, Bhagwagar Z, Cowen P. Decreased sensitivity of 5-HT1D receptors in melancholic depression. The British Journal Of Psychiatry 2001, 178: 454-457. PMID: 11331562, DOI: 10.1192/bjp.178.5.454.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGrowth hormone responseGrowth hormone releaseSSRI treatmentMajor depressionHormone releaseMelancholic depressionHormone responseBrain serotonin functionSerotonin reuptake inhibitorsReuptake inhibitorsDepressive syndromeReceptor agonistReceptor subtypesSerotonin functionHealthy subjectsReceptor sensitivityPatientsControl groupMarked reductionZolmitriptanDepressionReceptorsTreatmentSelective ligands