2024
Thursday, July 11, 20244:00 PM - 5:00 PM PP01 Presentation Time: 4:00 PM Investigating Shielding as a Dose-Shaping Tool in Flattening Distal Dose Profiles for Single-Channel Vaginal Cylinders
Tien C, Mullane S, Draeger E, Rivard M, Chen Z. Thursday, July 11, 20244:00 PM - 5:00 PM PP01 Presentation Time: 4:00 PM Investigating Shielding as a Dose-Shaping Tool in Flattening Distal Dose Profiles for Single-Channel Vaginal Cylinders. Brachytherapy 2024, 23: s26-s27. DOI: 10.1016/j.brachy.2024.08.020.Peer-Reviewed Original ResearchModel-based dose calculation algorithmsSingle-channel vaginal cylinderDose profilesDose distributionVaginal cylinderCentral axisCustomized shieldingRegions of high doseAnisotropic dose distributionUniform dose profileDose calculation algorithmWater-equivalent materialDose calculation methodMonte CarloIr-192 seedsDose gridIr-192MC simulationsRelative doseShielding materialsCalculation algorithmSource transitionDose optimizationLateral radiusShieldingPO0116 Design and Characterization of a Brachytherapy Applicator with Modulated Shielding (MOSH) for the Treatment of Cervical Cancer
Schwipper C, Mullane S, Draeger E, Chen Z, Rivard M, Tien C. PO0116 Design and Characterization of a Brachytherapy Applicator with Modulated Shielding (MOSH) for the Treatment of Cervical Cancer. Brachytherapy 2024, 23: s92. DOI: 10.1016/j.brachy.2024.08.134.Peer-Reviewed Original ResearchDose distributionBrachytherapy applicationsOAR dosesIr-192TG-43 dose calculation formalismShield geometryReduces dose to OARAAPM TG-43 formalismShielding materialsDose calculation formalismHigh-Z shieldingReduced OAR dosesCalculated dose distributionsTG-43 formalismDose-volume objectivesDose to OARsTreatment of cervical cancerHDR brachytherapy applicatorsHigh-risk clinical target volumeIr-192 sourceImproved dose distributionClinical target volumeSparing OARsTOPAS MCYb-169AAPM Task Group Report 267: A joint AAPM GEC‐ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy
Chen Z, Li X, Brenner D, Hellebust T, Hoskin P, Joiner M, Kirisits C, Nath R, Rivard M, Thomadsen B, Zaider M. AAPM Task Group Report 267: A joint AAPM GEC‐ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy. Medical Physics 2024, 51: 3850-3923. PMID: 38721942, DOI: 10.1002/mp.17062.Peer-Reviewed Original ResearchDose delivery patternClinical medical physicistsBrachytherapy modalitiesMedical physicistsAAPM Task Group ReportAmerican Association of PhysicsBrachytherapy treatment planningTask group reportRadioactive sourcesDevelopment of biophysical modelsEuropean Society for Radiotherapy & OncologyGEC-ESTRORadiobiological effectsAAPMRadiation oncologyBrachytherapyBiophysical modelTreatment planningPhysicistsClinical effectsClinical backgroundIrradiated tissueDelivery patternsPractice guidelinesTreatment techniques
2023
Editorial: Innovations, advances, and challenges in precision radiation oncology physics
Guan F, Bronk L, Yue J, Mohan R, Chen Z. Editorial: Innovations, advances, and challenges in precision radiation oncology physics. Precision Radiation Oncology 2023, 7: 222-224. DOI: 10.1002/pro6.1216.Peer-Reviewed Original ResearchPO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay?
Guan F, Draeger E, Carlson D, Chen Z, Tien C. PO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay? Brachytherapy 2023, 22: s97-s98. DOI: 10.1016/j.brachy.2023.06.162.Peer-Reviewed Original ResearchPO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model
Tien C, Draeger E, Guan F, Carlson D, Chen Z. PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. Brachytherapy 2023, 22: s110. DOI: 10.1016/j.brachy.2023.06.184.Peer-Reviewed Original ResearchTumor control probabilityClinical trialsLinear-quadratic modelNumber of patientsPatient cohort sizeTCP curvesRadiobiological parametersVirtual clinical trialsGy-1Cohort sizeRange of dosesPatient outcomesReference cohortPatientsHeterogeneous cohortVirtual patientsNew trialsRadiobiological parameter valuesClonogenic populationPatient ordersControl probabilityGyInput model parametersTrialsCohortCharacterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons
Guan F, Chen H, Draeger E, Li Y, Aydin R, Tien C, Chen Z. Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons. Precision Radiation Oncology 2023, 7: 84-91. DOI: 10.1002/pro6.1204.Peer-Reviewed Original ResearchX-ray beamMeV electron beamMV photon beamElectron beamMV photonsBeam energyMeV electronsPhoton beamsEnergy dependenceKilovoltage x-ray beamsMinimal energy dependenceClinical photonPhotonsBeamRadiation typesMeVElectronsDependence experimentsFilmsDose-response dependenceResponse dependenceDependenceEnergyNoise ratioEBT3Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy
Tien C, Chen Z. Radiobiological evaluation of the stepping-source effect in single-fraction monotherapy high-dose-rate prostate brachytherapy. Brachytherapy 2023, 22: 593-606. PMID: 37263898, DOI: 10.1016/j.brachy.2023.03.003.Peer-Reviewed Original ResearchDosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons
Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons. Precision Radiation Oncology 2023, 7: 15-26. PMID: 37868341, PMCID: PMC10586355, DOI: 10.1002/pro6.1187.Peer-Reviewed Original ResearchLinear energy transferEBT-XD filmsTherapeutic protonsFilm calibrationProton linear energy transferUltra-high Dose Rate FLASH RadiotherapyDynamic dose rangeMV photon beamDose-averaged LET valuesDose rate dependenceProton beamlineProton beamPhoton beamsFLASH beamSpot scanning proton beamsDosimetric responseLET dependenceFLASH radiotherapyHigh-dose applicationFilm responseLET valuesEnergy transferBeamProtonsGafchromicDose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study
Das I, Yadav P, Andersen A, Chen Z, Huang L, Langer M, Lee C, Li L, Popple R, Rice R, Schiff P, Zhu T, Abazeed M. Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study. Radiotherapy And Oncology 2023, 182: 109571. PMID: 36822361, PMCID: PMC10121952, DOI: 10.1016/j.radonc.2023.109571.Peer-Reviewed Original ResearchConceptsDose prescriptionTreatment-related toxicityClinical outcome comparisonStereotactic body radiotherapyMulti-institutional studyTreatment guidelinesTreatment disparitiesBody radiotherapyPTV volumeClinical trialsTreatment protocolOutcome comparisonsTreatment efficacyAbstractTextHypofractionated treatmentDosimetric parametersDose parametersDosimetric variabilityDosimetric variationsStandardized reportingLack of standardizationPreliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems
Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.Peer-Reviewed Original ResearchConceptsConformity indexRadiation Therapy Oncology Group conformity indexGK plansSuperior conformity indexNon-metastatic casesPaddick conformity indexDosimetric plan qualityGK patientsBrain metastasesRadiosurgery systemTrigeminal neuralgiaPrescription dosesGamma Knife systemMetastatic casesArteriovenous malformationsPituitary adenomasConformality indexLarge cohortDosimetric comparisonStereotactic radiosurgery systemGK IconPatientsCohortTreatment timeDosimetric results
2022
Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment
Donahue W, Draeger E, Han D, Chen Z. Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment. Journal Of Applied Clinical Medical Physics 2022, 24: e13868. PMID: 36527239, PMCID: PMC10113690, DOI: 10.1002/acm2.13868.Peer-Reviewed Original ResearchConceptsInformation systemsTransfer of dataPlanning systemSoftware systemsOncology information systemMultiple vendorsData transferField labelsData inputTimer settingsNumber of errorsTechnological advancementsErrorSystemVendorsAdvancementTreatment planning systemFrequency of errorsMOSAIQCommon errorsLabelsInformationPHSOR05 Presentation Time: 12:50 PM The Effect of Quantum Noise on a Novel Multilateration-Based Brachytherapy Source Localization Approach
Jensen P, Tien C, Chen Z. PHSOR05 Presentation Time: 12:50 PM The Effect of Quantum Noise on a Novel Multilateration-Based Brachytherapy Source Localization Approach. Brachytherapy 2022, 21: s25-s26. DOI: 10.1016/j.brachy.2022.09.023.Peer-Reviewed Original ResearchQuantum noiseSource positionAcquisition timePixel sizePhoton-counting systemParticle detectorsImage fluxesLarge pixel sizeDominant sourceAchievable resolutionPhysics principlesSource strengthAxis displacementCamera systemPoint sourcesParameter rangeSingle camera systemSecond cameraDose reconstructionSystem setupRadiation doseCentral axisDual-camera systemPhotonsSetupPHSPP04 Presentation Time: 3:00 PM The Impact of Sublethal Damage Repair on Biological Dose for a Stepping-Source Brachytherapy Delivery in a Single-Fraction Prostate Treatment
Tien C, Donahue W, Giles D, Chen Z. PHSPP04 Presentation Time: 3:00 PM The Impact of Sublethal Damage Repair on Biological Dose for a Stepping-Source Brachytherapy Delivery in a Single-Fraction Prostate Treatment. Brachytherapy 2022, 21: s32-s33. DOI: 10.1016/j.brachy.2022.09.034.Peer-Reviewed Original ResearchA small footprint couch‐top support device for image‐guided radiotherapy of heavy patients
Chen H, Morley K, Rodriguez R, Draeger E, Hassan M, Chen Z. A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients. Journal Of Applied Clinical Medical Physics 2022, 23: e13788. PMID: 36267043, PMCID: PMC9797158, DOI: 10.1002/acm2.13788.Peer-Reviewed Original ResearchSkin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET)
Ding G, Chen Z, Zhong W, Zhu T. Skin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET). Medical Physics 2022, 49: 6646-6653. PMID: 35972019, DOI: 10.1002/mp.15907.Peer-Reviewed Original ResearchConceptsTotal skin electron therapyDose coverageStanford techniqueAdvanced-stage cutaneous T-cell lymphomaCutaneous T-cell lymphomaSkin dose distributionRotational techniqueT-cell lymphomaPatient's postureSimilar dose coverageDose distributionExtended treatment distancesElectron therapyMean doseEffective treatmentSame patientSmall dose differencesClinical settingPatient treatmentSkin dosesRealistic clinical settingsSkin doseDoseDifferent posturesDistribution of doseDosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy
Tien CJ, Damast S, Chen ZJ. Dosimetric study of Varian Universal Multi-Channel Cylinder System for High-Dose-Rate 192Ir Brachytherapy. Brachytherapy 2022, 21: 244-254. PMID: 34996715, DOI: 10.1016/j.brachy.2021.11.001.Peer-Reviewed Original Research
2021
Reflections on Anthony Zietman From Gastrointestinal Cancer and Physics Editors
Willett GCECG, Chang DT, Czito BG, Liauw SL, Wo JY, Klein PEE, Chen Z, Carlson DJ, Chetty IJ. Reflections on Anthony Zietman From Gastrointestinal Cancer and Physics Editors. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 1114-1117. PMID: 34793734, DOI: 10.1016/j.ijrobp.2021.09.007.Peer-Reviewed Original ResearchPO03 A Novel Design in Peripheral Channels of a Brachytherapy Multichannel Applicator Demonstrates Significant Differences in Dose to Surrounding Volume
Tien C, Damast S, Young M, Kaur M, Kim J, Chen Z. PO03 A Novel Design in Peripheral Channels of a Brachytherapy Multichannel Applicator Demonstrates Significant Differences in Dose to Surrounding Volume. Brachytherapy 2021, 20: s56-s57. DOI: 10.1016/j.brachy.2021.06.091.Peer-Reviewed Original Research
2020
Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
Draeger E, Pinkham DW, Chen ZJ, Tien CJ. Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy. Brachytherapy 2020, 20: 401-409. PMID: 33288488, DOI: 10.1016/j.brachy.2020.09.019.Peer-Reviewed Original Research