2017
Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas
King AR, Corso CD, Chen EM, Song E, Bongiorni P, Chen Z, Sundaram RK, Bindra RS, Saltzman WM. Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas. Molecular Cancer Therapeutics 2017, 16: 1456-1469. PMID: 28566437, PMCID: PMC5545124, DOI: 10.1158/1535-7163.mct-16-0788.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasPoor blood-brain barrier penetrationLocal disease progressionBlood-brain barrier penetrationEffect of radiotherapyIntrinsic pontine gliomaTreatment of glioblastomaMol Cancer TherCranial radiationDosing schedulesMultimodal treatmentIntracranial gliomasDisease progressionExtracranial tumorsPontine gliomaAggressive phenotypeRadiotherapy approachesGliomasMinimal toxicityRadiotherapyGlioblastomaBarrier penetrationTreatmentRadiosensitizerChemotherapy
2005
Dose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures
Nath R, Bongiorni P, Chen Z, Gragnano J, Rockwell S. Dose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures. International Journal Of Radiation Biology 2005, 81: 689-699. PMID: 16368647, DOI: 10.1080/09553000500401551.Peer-Reviewed Original ResearchConceptsContinuous low dose rate irradiationDose rate irradiationLow dose rate irradiationRate irradiationInterstitial brachytherapyHigh dose rate irradiationAcute exposureRhabdomyosarcoma cellsPermanent interstitial brachytherapyRelative biological effectivenessBA1112 tumorsSame dose rateSurvival curvesHigh linear energy transferAcute irradiationTumor cellsCell survival curvesBiological effectivenessLow dose rateDose-rate effectDose rateBrachytherapy