CASK Deletion in Intestinal Epithelia Causes Mislocalization of LIN7C and the DLG1/Scrib Polarity Complex without Affecting Cell Polarity
Lozovatsky L, Abayasekara N, Piawah S, Walther Z. CASK Deletion in Intestinal Epithelia Causes Mislocalization of LIN7C and the DLG1/Scrib Polarity Complex without Affecting Cell Polarity. Molecular Biology Of The Cell 2009, 20: 4489-4499. PMID: 19726564, PMCID: PMC2770937, DOI: 10.1091/mbc.e09-04-0280.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorEpithelial polarityNormal localizationBasolateral membranePolarity complexMammalian orthologsCell polarityCaenorhabditis elegansMAGUK familyProtein complexesIntestinal epitheliumGrowth factor receptorLIN7CBasolateral localizationComplete knockoutCASK expressionTumor suppressorSubcellular distributionDlg1CASK deletionFactor receptorImmunofluorescence analysisErbB-2Intestinal homeostasisAppropriate localization