2018
Inhibition of endo-lysosomal function exacerbates vascular calcification
Cai Y, Wang XL, Flores AM, Lin T, Guzman RJ. Inhibition of endo-lysosomal function exacerbates vascular calcification. Scientific Reports 2018, 8: 3377. PMID: 29467541, PMCID: PMC5821871, DOI: 10.1038/s41598-017-17540-6.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVascular calcificationAortic rings ex vivoChronic kidney diseaseMedial artery calcificationSmooth muscle cellsLysosomal inhibitor chloroquineCardiovascular morbidityArtery calcificationPathologic responseDiabetes mellitusAortic ringsKidney diseaseMedial calcificationVitamin D3Osteogenic transformationVSMC calcificationLysosomal marker lysosomeProtective roleLysosome inhibitionInhibitor chloroquineMembrane protein 2Ex vivoMuscle cellsCalcification
2016
Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification
Lin T, Wang XL, Zettervall SL, Cai Y, Guzman RJ. Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification. Journal Of Vascular Surgery 2016, 66: 586-593. PMID: 27374065, PMCID: PMC5201454, DOI: 10.1016/j.jvs.2016.03.462.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicAortic DiseasesBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsCells, CulturedHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleOrgan Culture TechniquesOsteogenesisPhosphatesPyrazolesQuinolinesRats, Sprague-DawleySignal TransductionVascular CalcificationConceptsMedial artery calcificationSmooth muscle cellsArtery calcificationMedial calcificationOrgan culture modelVascular patientsVascular calcificationWestern blotCalcium accumulationHuman aortic smooth muscle cellsChronic kidney diseaseCulture modelVascular smooth muscle cellsAortic smooth muscle cellsQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionSMC markersTranscription-polymerase chain reactionHuman smooth muscle cellsAortic medial calcificationMuscle myosin heavy chainHomologue 1Bone morphogenetic proteinKidney diseasePolymerase chain reaction