Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification
Zettervall SL, Wang X, Monk S, Lin T, Cai Y, Guzman RJ. Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification. Physiological Reports 2021, 9: e15008. PMID: 34405571, PMCID: PMC8371346, DOI: 10.14814/phy2.15008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriesCholecalciferolHindlimbMalePeripheral Arterial DiseaseRatsRats, Sprague-DawleyReperfusion InjuryVascular CalcificationConceptsPeripheral artery diseaseMedial artery calcificationFemoral artery ligationVehicle-injected ratsMedial calcificationHindlimb ischemiaArtery calcificationLimb ischemiaArtery ligationFunctional recoveryArterial calcificationLaser Doppler perfusion imagingAcute limb ischemiaChronic kidney diseaseRecovery of perfusionVascular smooth muscle cellsSmooth muscle cellsLower extremity vesselsAmputation rateArtery diseaseArterial stiffnessClinical outcomesImpaired perfusionKidney diseaseLimb perfusion