Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif
Hu Y, Gudnadóttir R, Knecht K, Arizaga F, Jónsson S, Xiong Y. Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif. Science Advances 2023, 9: eadd3422. PMID: 36638173, PMCID: PMC9839330, DOI: 10.1126/sciadv.add3422.Peer-Reviewed Original ResearchConceptsMVV VifCryo-electron microscopy structureE3 ubiquitin ligase complexLentiviral VifUbiquitin ligase complexHost cofactorsUbiquitin-proteasome pathwayDistinct interaction modesUnique structural elementsLentiviral Vif proteinsEvolutionary relationshipsMicroscopy structureLigase complexCellular proteinsE3 ubiquitinAntiviral APOBEC3Structural basisFunctional analysisMolecular mechanismsMaedi-visna virusRecruitment mechanismsVif proteinCofactorProteinCypA