Yibo Xi, PhD
Associate Research ScientistCards
About
Research
Publications
2024
Acyl-CoA Synthetase Medium-Chain Family Member 5-Mediated Fatty Acid Metabolism Dysregulation Promotes the Progression of Hepatocellular Carcinoma.
Yang L, Pham K, Xi Y, Jiang S, Robertson KD, Liu C. Acyl-CoA Synthetase Medium-Chain Family Member 5-Mediated Fatty Acid Metabolism Dysregulation Promotes the Progression of Hepatocellular Carcinoma. Am J Pathol 2024, 194: 1951-1966. PMID: 39069168, DOI: 10.1016/j.ajpath.2024.07.002.Peer-Reviewed Original ResearchOral 8-aminoguanine against age-related retinal degeneration.
Chen Y, Vats A, Xi Y, Wolf-Johnston A, Clinger O, Arbuckle R, Dermond C, Li J, Stolze D, Sahel JA, Jackson E, Birder L. Oral 8-aminoguanine against age-related retinal degeneration. Res Sq 2024 PMID: 38765984, DOI: 10.21203/rs.3.rs-4022389/v1.Peer-Reviewed Original Research In Press
2023
The 18th amino acid glycine plays an essential role in maintaining the structural stabilities of γS-crystallin linking with congenital cataract.
Zhu S, Xi Y, Xu J, Hu L, Luo C, Yao K, Chen X. The 18th amino acid glycine plays an essential role in maintaining the structural stabilities of γS-crystallin linking with congenital cataract. Int J Biol Macromol 2023, 251: 126339. PMID: 37586630, DOI: 10.1016/j.ijbiomac.2023.126339.Peer-Reviewed Original Research
2022
Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure.
Peng G, Xi Y, Bellini C, Pham K, Zhuang ZW, Yan Q, Jia M, Wang G, Lu L, Tang MS, Zhao H, Wang H. Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure. American Journal Of Cancer Research 2022, 12: 3679-3692. PMID: 36119846, PMCID: PMC9442002.Peer-Reviewed Original ResearchElectronic cigarette exposureCigarette exposureMale ApoE-/- miceApoE-/- miceCytokine mRNA expressionPoor health outcomesWhite blood cellsElectronic cigarette useDose-dependent mannerE-cigarette aerosolAerosol inhalationCigarette smokingActivation of MAPKHigher nicotine concentrationsMAPK pathway activationCell-damaging effectsCpG sitesHealth outcomesCigarette useMRNA expressionNicotine concentrationsPathway activationSignificant CpG sitesBlood cellsSignificant alterationsCelastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens.
Wang H, Tian Q, Zhang Y, Xi Y, Hu L, Yao K, Li J, Chen X. Celastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens. Fundam Res 2022, 4: 394-400. PMID: 38933503, DOI: 10.1016/j.fmre.2022.05.012.Peer-Reviewed Original ResearchNonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa.
Vats A, Xi Y, Feng B, Clinger OD, St Leger AJ, Liu X, Ghosh A, Dermond CD, Lathrop KL, Tochtrop GP, Picaud S, Chen Y. Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa. JCI Insight 2022, 7 PMID: 35472194, DOI: 10.1172/jci.insight.153717.Peer-Reviewed Original ResearchEmerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma
Crane J, Shi Q, Xi Y, Lai J, Pham K, Wang H. Emerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma. Journal Of Clinical And Translational Pathology 2022, 2: 31-36. PMID: 36275841, PMCID: PMC9585478, DOI: 10.14218/jctp.2022.00004.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaSquamous cell carcinomaCell carcinomaHuman papillomavirusHuman papillomavirus-positive oropharyngeal squamous cell carcinomaHPV-positive oropharyngeal squamous cell carcinomaHPV-negative oropharyngeal squamous cell carcinomaActive human papillomavirusNew targetsLong-term survivalPotential new targetsDefinitive treatmentHPV 16Treatment optionsSurvival prognosisTumor prognosisAdvanced stageHealth responsePrecision treatmentPrecision medicinePatientsCarcinomaPrognosisTreatmentPathological researchPharmacological strategies for treating misfolded rhodopsin-associated autosomal dominant retinitis pigmentosa.
Xi Y, Chen Y. Pharmacological strategies for treating misfolded rhodopsin-associated autosomal dominant retinitis pigmentosa. Neural Regen Res 2022, 17: 110-112. PMID: 34100444, DOI: 10.4103/1673-5374.314306.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
A novel F30S mutation in γS-crystallin causes autosomal dominant congenital nuclear cataract by increasing susceptibility to stresses.
Wang KJ, Liao XY, Lin K, Xi YB, Wang S, Wan XH, Yan YB. A novel F30S mutation in γS-crystallin causes autosomal dominant congenital nuclear cataract by increasing susceptibility to stresses. Int J Biol Macromol 2021, 172: 475-482. PMID: 33454329, DOI: 10.1016/j.ijbiomac.2021.01.079.Peer-Reviewed Original Research
2018
Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.
Yang X, Chen XJ, Yang Z, Xi YB, Wang L, Wu Y, Yan YB, Rao Y. Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation. J Med Chem 2018, 61: 8693-8706. PMID: 30153006, DOI: 10.1021/acs.jmedchem.8b00705.Peer-Reviewed Original Research