2024
Group Response‐Adaptive Randomization With Delayed and Missing Responses
Zhai G, Li Y, Zhang L, Hu F. Group Response‐Adaptive Randomization With Delayed and Missing Responses. Statistics In Medicine 2024, 43: 5047-5059. PMID: 39285137, DOI: 10.1002/sim.10220.Peer-Reviewed Original ResearchMeSH KeywordsBiasComputer SimulationHumansModels, StatisticalRandom AllocationRandomized Controlled Trials as TopicResearch DesignTime FactorsSequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance
Yang H, Qin Y, Li Y, Hu F. Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance. Biometrics 2024, 80: ujae047. PMID: 38801258, DOI: 10.1093/biomtc/ujae047.Peer-Reviewed Original ResearchConceptsCovariate balanceMarginal imbalanceAdaptive randomization methodsTreatment effect estimatesSequential allocation schemeModified Mahalanobis distanceRandomization methodSimulation studyCovariate imbalanceRandom processTheoretical guaranteesCovariatesImbalance measureEffect estimatesMahalanobis distanceCurrent patientSample size differencesMarginal balanceAllocation schemeConvergenceData analysisSuperior performance
2022
Network-based cancer heterogeneity analysis incorporating multi-view of prior information
Li Y, Xu S, Ma S, Wu M. Network-based cancer heterogeneity analysis incorporating multi-view of prior information. Bioinformatics 2022, 38: 2855-2862. PMID: 35561185, PMCID: PMC9113254, DOI: 10.1093/bioinformatics/btac183.Peer-Reviewed Original Research
2021
Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates
Li Y, Ma W, Qin Y, Hu F. Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates. Statistical Methods In Medical Research 2021, 30: 2148-2164. PMID: 33899607, DOI: 10.1177/09622802211008206.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationLinear ModelsLogistic ModelsModels, StatisticalRandom AllocationRandomized Controlled Trials as TopicResearch DesignConceptsCovariate-adaptive randomizationCovariate-adaptive randomization methodsCovariate-adaptive randomized trialsValidity of statistical inferenceInflated type I errorLinear modelType I errorGeneralized linear modelAsymptotic distributionProposed adjustment methodAsymptotic resultsInferential propertiesTest statisticsAnti-conservativeStatistical inferenceContinuous responseUnadjusted testsNull hypothesisTheoretical findingsTreatment effectsInvalid testsRandomization methodNumerical studyCovariatesAdjustment method