2024
Group Response‐Adaptive Randomization With Delayed and Missing Responses
Zhai G, Li Y, Zhang L, Hu F. Group Response‐Adaptive Randomization With Delayed and Missing Responses. Statistics In Medicine 2024, 43: 5047-5059. PMID: 39285137, DOI: 10.1002/sim.10220.Peer-Reviewed Original ResearchMeSH KeywordsBiasComputer SimulationHumansModels, StatisticalRandom AllocationRandomized Controlled Trials as TopicResearch DesignTime FactorsSequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance
Yang H, Qin Y, Li Y, Hu F. Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance. Biometrics 2024, 80: ujae047. PMID: 38801258, DOI: 10.1093/biomtc/ujae047.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBiometryComputer SimulationData Interpretation, StatisticalHumansModels, StatisticalRandom AllocationRandomized Controlled Trials as TopicSample SizeConceptsCovariate balanceMarginal imbalanceAdaptive randomization methodsTreatment effect estimatesSequential allocation schemeModified Mahalanobis distanceRandomization methodSimulation studyCovariate imbalanceRandom processTheoretical guaranteesCovariatesImbalance measureEffect estimatesMahalanobis distanceCurrent patientSample size differencesMarginal balanceAllocation schemeConvergenceData analysisSuperior performance
2021
Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates
Li Y, Ma W, Qin Y, Hu F. Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates. Statistical Methods In Medical Research 2021, 30: 2148-2164. PMID: 33899607, DOI: 10.1177/09622802211008206.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationLinear ModelsLogistic ModelsModels, StatisticalRandom AllocationRandomized Controlled Trials as TopicResearch DesignConceptsCovariate-adaptive randomizationCovariate-adaptive randomization methodsCovariate-adaptive randomized trialsValidity of statistical inferenceInflated type I errorLinear modelType I errorGeneralized linear modelAsymptotic distributionProposed adjustment methodAsymptotic resultsInferential propertiesTest statisticsAnti-conservativeStatistical inferenceContinuous responseUnadjusted testsNull hypothesisTheoretical findingsTreatment effectsInvalid testsRandomization methodNumerical studyCovariatesAdjustment method