2017
Elevated T cell activation score is associated with improved survival of breast cancer
Lu L, Bai Y, Wang Z. Elevated T cell activation score is associated with improved survival of breast cancer. Breast Cancer Research And Treatment 2017, 164: 689-696. PMID: 28488141, DOI: 10.1007/s10549-017-4281-x.Peer-Reviewed Original ResearchConceptsT cell activation scoreBreast cancer patientsOverall survivalPatients' overall survivalCancer patientsImproved survivalPD-1Activation scoresBreast cancerCell death-1 receptorLow PD-1 expressionMultivariate Cox regression analysisT-lymphocyte antigen-4Kaplan-Meier survival curvesT cell activation statusDeath-1 receptorPD-1 expressionEffector T cellsImmune checkpoint blockadeCox regression analysisPoor overall survivalCox regression modelT cell functionActivation groupCell activation status
2005
Recruitment of CXCR3+ and CCR5+ T Cells and Production of Interferon-γ-Inducible Chemokines in Rejecting Human Arteries
Burns WR, Wang Y, Tang PC, Ranjbaran H, Iakimov A, Kim J, Cuffy M, Bai Y, Pober JS, Tellides G. Recruitment of CXCR3+ and CCR5+ T Cells and Production of Interferon-γ-Inducible Chemokines in Rejecting Human Arteries. American Journal Of Transplantation 2005, 5: 1226-1236. PMID: 15888026, DOI: 10.1111/j.1600-6143.2005.00892.x.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBlood VesselsCells, CulturedChemokine CCL4Chemokine CCL5Chemokine CXCL10Chemokine CXCL11Chemokine CXCL9Chemokines, CXCEndothelial CellsGraft RejectionHeart TransplantationHumansIntercellular Signaling Peptides and ProteinsInterferon-gammaLeukocytesMacrophage Inflammatory ProteinsMuscle, Smooth, VascularReceptors, CCR5Receptors, ChemokineReceptors, CXCR3Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerT-LymphocytesTransplantation, HomologousVascular DiseasesConceptsT cellsIFN-gamma-secreting T cellsClinical allograft rejectionRecruitment of CXCR3Allogeneic T cellsVascular smooth muscle cellsExpression of chemokinesCoronary artery segmentsProduction of interferonDifferent vascular compartmentsSmooth muscle cellsReal-time RT-PCRImmunodeficient mouse hostsAcute rejectionAllograft rejectionInducible chemokinesMicrovascular inflammationConduit arteriesIP-10MIP-1betaImmunological privilegeTh1 cellsChemokine mRNAChemokine receptorsI-TAC
2002
CD2 is a Dominant Target for Allogeneic Responses
Bai Y, Fu S, Honig S, Wang Y, Qin L, Chen D, Bromberg JS. CD2 is a Dominant Target for Allogeneic Responses. American Journal Of Transplantation 2002, 2: 618-626. PMID: 12201362, DOI: 10.1034/j.1600-6143.2002.20706.x.Peer-Reviewed Original ResearchConceptsAlloantigen-driven proliferationIndefinite allograft survivalAntigen-presenting cellsT cellsAllograft survivalCardiac allograft recipientsProlong graft survivalT cell responsesCombination of mAbsIFN-gamma productionAllograft recipientsMAb administrationGraft survivalNK cytotoxicityAllograft rejectionCytokine responsesAllogeneic responseSurvival resultsPotent regulatory moleculesSingle MAbAnti-CD48B cellsMAbs resultsInhibitory mAbsMAbsL-Selectin-Dependent Lymphoid Occupancy Is Required to Induce Alloantigen-Specific Tolerance
Bai Y, Liu J, Wang Y, Honig S, Qin L, Boros P, Bromberg JS. L-Selectin-Dependent Lymphoid Occupancy Is Required to Induce Alloantigen-Specific Tolerance. The Journal Of Immunology 2002, 168: 1579-1589. PMID: 11823485, DOI: 10.4049/jimmunol.168.4.1579.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell MovementCells, CulturedFingolimod HydrochlorideGraft SurvivalHeart TransplantationImmunosuppressive AgentsIsoantigensKineticsL-SelectinLymph NodesLymphocyte ActivationLymphoid TissueMiceMice, KnockoutPropylene GlycolsSphingosineSpleenT-LymphocytesTransplantation ToleranceConceptsAlloantigen-specific toleranceIndefinite allograft survivalAllograft survivalLymph nodesT cellsLymph node homingSecondary lymphoid organsWild-type recipientsImmunosuppressive regimenPeripheral tolerizationCardiac allograftsAdoptive transferConcurrent administrationPeripheral bloodLymphoid organsLymphoid tissueHistologic examinationHoming receptorImmune regulationT lymphocytesTolerizationAg processingAlloantigensImmunosuppressantsLymphocytes