The feasibility of high-dose chemotherapy in breast cancer patients with impaired left ventricular function
Rose M, Lee F, Gollerkeri A, D'Andrea E, Psyrri A, Bdolah-Abram T, Burtness B. The feasibility of high-dose chemotherapy in breast cancer patients with impaired left ventricular function. Bone Marrow Transplantation 2000, 26: 133-139. PMID: 10918422, DOI: 10.1038/sj.bmt.1702449.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCombined Modality TherapyCyclophosphamideDoxorubicinFemaleFollow-Up StudiesHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHumansMiddle AgedNeutropeniaPaclitaxelStroke VolumeSurvival RateVentricular Dysfunction, LeftConceptsLeft ventricular ejection fractionHigh-dose chemotherapyBreast cancer patientsMean absolute decreaseCancer patientsAbsolute decreaseLV functionCell rescueImpaired left ventricular functionHigh-dose thiotepaImpaired LV functionHigh-dose melphalanStem cell rescueSymptomatic heart failureCourses of chemotherapyVentricular ejection fractionLeft ventricular functionSequential paclitaxelMetastatic diseaseCardiac deathCardiac symptomsEjection fractionHeart failureVentricular functionCardiac toxicity