2014
A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
Konieczkowski D, Johannessen C, Abudayyeh O, Kim J, Cooper Z, Piris A, Frederick D, Barzily-Rokni M, Straussman R, Haq R, Fisher D, Mesirov J, Hahn W, Flaherty K, Wargo J, Tamayo P, Garraway L. A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors. Cancer Discovery 2014, 4: 816-827. PMID: 24771846, PMCID: PMC4154497, DOI: 10.1158/2159-8290.cd-13-0424.Peer-Reviewed Original ResearchMeSH KeywordsAnilidesBenzimidazolesBenzocycloheptenesCell Line, TumorCells, CulturedDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHepatocyte Growth FactorHumansIndolesMAP Kinase Signaling SystemMelanocytesMelanomaMicrophthalmia-Associated Transcription FactorNF-kappa B p50 SubunitProtein Kinase InhibitorsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-metPyridinesQuinolinesSulfonamidesTriazolesConceptsBRAF(V600)-mutant melanomaMAPK pathway inhibitorsNF-kB activationPathway inhibitorNF-kBMelanocyte lineage transcription factor MITFCell linesDrug-sensitive cell linesResistance to MAPK pathway inhibitorsMITF expressionReceptor tyrosine kinase AXLTranscription factor MITFTyrosine kinase AXLResistance marker genesResistant cell linesNF-kB signalingResistant to inhibitionClinical benefitPatient biopsiesMEK inhibitorsTranscriptional profilesOncogenic BRAF(V600EDrug resistanceInhibitor sensitivityCell states
2010
An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells
Nikitin P, Yan C, Forte E, Bocedi A, Tourigny J, White R, Allday M, Patel A, Dave S, Kim W, Hu K, Guo J, Tainter D, Rusyn E, Luftig M. An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells. Cell Host & Microbe 2010, 8: 510-522. PMID: 21147465, PMCID: PMC3049316, DOI: 10.1016/j.chom.2010.11.004.Peer-Reviewed Original ResearchMeSH KeywordsAtaxia Telangiectasia Mutated ProteinsB-LymphocytesCell Cycle ProteinsCell ProliferationCell Transformation, ViralCells, CulturedCheckpoint Kinase 2DNA DamageDNA-Binding ProteinsEpstein-Barr Virus Nuclear AntigensHerpesvirus 4, HumanHumansProtein Serine-Threonine KinasesSignal TransductionTumor Suppressor ProteinsConceptsDNA damage responseEpstein-Barr virusPrimary human B cellsHuman B cellsB cellsTumor suppressor mechanismSuppressor mechanismViral latency productsProliferating lymphoblastoid cell linesPrimary B cellsInduce cell immortalizationLymphoblastoid cell linesDDR kinase ATMEarly cell divisionsDNA damage response activationLytic viral replicationIncreased transformation efficiencyLatent episomeKinase ATMImmortalization efficiencyCell divisionHuman malignanciesDamage responseCell immortalizationViral replication