2023
Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis
Mohammed S, Thadathil N, Ohene-Marfo P, Tran A, Van Der Veldt M, Georgescu C, Oh S, Nicklas E, Wang D, Haritha N, Luo W, Janknecht R, Miller B, Wren J, Freeman W, Deepa S. Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis. Molecular Cancer Research 2023, 21: 933-946. PMID: 37204757, PMCID: PMC10472095, DOI: 10.1158/1541-7786.mcr-22-0820.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseProgression of NAFLDHepatocellular carcinomaChronic inflammationLiver fibrosisMale miceMouse modelCholine-deficient high-fat dietFemale wild-type miceOncogenic pathwaysFatty liver diseaseMarkers of inflammationHigh-fat dietLow-fat dietDevelopment of inflammationValid therapeutic targetWild-type miceHepatic inflammationInflammation contributesLiver diseaseWT miceFemale miceSex-specific differencesInflammationTherapeutic target
2020
Role of miR‐130b/301b cluster in macrophage polarization and obesity
Jiang S, McBride A, Luo W, Chernausek S. Role of miR‐130b/301b cluster in macrophage polarization and obesity. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.09682.Peer-Reviewed Original ResearchDevelopment of obesityMacrophage polarizationKnockout miceMacrophage M1/M2 polarizationM1/M2 polarizationPro-inflammatory activationWhole-body energy expenditureHigh-fat dietEnergy expenditureAlternative macrophage activationWild-type miceWhite adipose tissueBody energy expenditureMacrophage activation statusBone marrow macrophagesPresent studyFat dietIL-4M2 polarizationType miceAlternative activationMacrophage activationAdipose tissueMetabolic diseasesActivation status