CO Rebinding to Protoheme: Investigations of the Proximal and Distal Contributions to the Geminate Rebinding Barrier
Ye X, Yu A, Georgiev G, Gruia F, Ionascu D, Cao W, Sage J, Champion P. CO Rebinding to Protoheme: Investigations of the Proximal and Distal Contributions to the Geminate Rebinding Barrier. Journal Of The American Chemical Society 2005, 127: 5854-5861. PMID: 15839683, PMCID: PMC2768272, DOI: 10.1021/ja042365f.Peer-Reviewed Original ResearchMeSH KeywordsCarbon MonoxideEntropyGlycerolHemeKineticsSpectroscopy, Fourier Transform InfraredSpectrum Analysis, RamanConceptsProximal imidazole ligandRebinding barrierImidazole ligandsCetyltrimethylammonium bromideMicelles of cetyltrimethylammonium bromideAbsence of imidazoleDifferent solvent conditionsFree energy barrierCO rebinding ratesLigation changesGeminate amplitudeCO recombinationEnthalpic barrierDistal pocketRebinding kineticsCO rebindingHistidine ligationEnergy barrierEntropic contributionsEnthalpic contributionSolvent conditionsLigation statesSolvent viscosityWeak ligandsLigand