Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders
Haller S, Linke J, Grassie H, Jones E, Pagliaccio D, Harrewijn A, White L, Naim R, Abend R, Mallidi A, Berman E, Lewis K, Kircanski K, Fox N, Silverman W, Kalin N, Bar-Haim Y, Brotman M. Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders. American Journal Of Psychiatry 2024, 181: 201-212. PMID: 38263879, PMCID: PMC11423803, DOI: 10.1176/appi.ajp.20220449.Peer-Reviewed Original ResearchCognitive-behavioral therapyAt-risk sampleAnxiety disordersWeeks of cognitive-behavioral therapyBlood oxygen level-dependent responsesFronto-parietal attention networkHealthy comparison youthFronto-parietal activityFronto-parietal networkRegional activity changesHealthy comparison childrenCBT effectsAt-riskTemperamental riskCognitive-behavioralLimbic responsesNeural differencesAnxiety patientsUnmedicated youthLimbic regionsTreatment-related changesSymptom changeComparison youthComparison childrenFunctional MRI