2024
Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders
Haller S, Linke J, Grassie H, Jones E, Pagliaccio D, Harrewijn A, White L, Naim R, Abend R, Mallidi A, Berman E, Lewis K, Kircanski K, Fox N, Silverman W, Kalin N, Bar-Haim Y, Brotman M. Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders. American Journal Of Psychiatry 2024, 181: 201-212. PMID: 38263879, PMCID: PMC11423803, DOI: 10.1176/appi.ajp.20220449.Peer-Reviewed Original ResearchCognitive-behavioral therapyAt-risk sampleAnxiety disordersWeeks of cognitive-behavioral therapyBlood oxygen level-dependent responsesFronto-parietal attention networkHealthy comparison youthFronto-parietal activityFronto-parietal networkRegional activity changesHealthy comparison childrenCBT effectsAt-riskTemperamental riskCognitive-behavioralLimbic responsesNeural differencesAnxiety patientsUnmedicated youthLimbic regionsTreatment-related changesSymptom changeComparison youthComparison childrenFunctional MRI
2019
Efficacy and mechanisms underlying a gamified attention bias modification training in anxious youth: protocol for a randomized controlled trial
Linke JO, Jones E, Pagliaccio D, Swetlitz C, Lewis KM, Silverman WK, Bar-Haim Y, Pine DS, Brotman MA. Efficacy and mechanisms underlying a gamified attention bias modification training in anxious youth: protocol for a randomized controlled trial. BMC Psychiatry 2019, 19: 246. PMID: 31391027, PMCID: PMC6686536, DOI: 10.1186/s12888-019-2224-2.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyContext of CBTBias modification trainingDot-probe taskAttentional biasAnxious youthAmygdala connectivityAnxiety disordersAttention bias modification trainingPrimary anxiety disorder diagnosisHealthy comparison youthAnxiety disorder diagnosisVisual searchThreat responsesNeurobiological correlatesComparison youthBehavioral therapyTraining elementsDisorder diagnosisEngaging gameNeuronal levelYouthPrevious findingsMixed resultsTask