2024
Long‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer
Taylor J, Kamat A, O'Donnell M, Annapureddy D, Howard J, Tan W, McElree I, Davaro F, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, Woldu S, Lotan Y. Long‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer. BJU International 2024 PMID: 39183466, DOI: 10.1111/bju.16509.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerBladder-sparing therapyUpfront RCRadical cystectomyCohort of patientsBladder cancerBCG-unresponsive NMIBCRetrospective cohort of patientsProgression to MIBCUpfront radical cystectomyCancer-specific survivalInstitutional review board approvalMetastasis-free survivalFood and Drug Administration criteriaRate of recurrenceReview board approvalLong-term outcomesStatistically significant differenceNodal diseaseRe-resectionSystemic immunotherapyIntravesical chemotherapyOncological outcomesOverall survivalOncological riskBladder-sparing Therapy for Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer: International Bladder Cancer Group Recommendations for Optimal Sequencing and Patient Selection
Li R, Hensley P, Gupta S, Al-Ahmadie H, Babjuk M, Black P, Brausi M, Bree K, Fernández M, Guo C, Horowitz A, Lamm D, Lerner S, Lotan Y, Mariappan P, McConkey D, Mertens L, Mir C, Ross J, O'Donnell M, Palou J, Pohar K, Steinberg G, Soloway M, Spiess P, Svatek R, Tan W, Taoka R, Buckley R, Kamat A. Bladder-sparing Therapy for Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer: International Bladder Cancer Group Recommendations for Optimal Sequencing and Patient Selection. European Urology 2024 PMID: 39183090, DOI: 10.1016/j.eururo.2024.08.001.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerInternational Bladder Cancer GroupBladder-sparing treatmentCarcinoma in situNadofaragene firadenovecRadical cystectomyBladder cancerOptimal selection of patientsAbsence of randomized trialsBladder-sparing therapySingle-agent chemotherapyBladder cancer groupSelection of patientsDevelopment of agentsPatient selectionSystemic toxicityCancer groupUnapproved agentsClinical trial participationPatient characteristicsRandomized trialsMitomycin CTumor attributesConsensus recommendationsCancer expertsMale Robot-Assisted Radical Cystectomy with Nerve Sparing Technique
Tan W, Ta A, Sridhar A, Kelly J. Male Robot-Assisted Radical Cystectomy with Nerve Sparing Technique. 2024, 291-302. DOI: 10.1007/978-3-031-49428-4_23.Peer-Reviewed Original ResearchONCOLOGIC OUTCOMES OF GEMCITABINE-DOCETAXEL COMBINATION INTRAVESICAL BLADDER SPARING THERAPY COMPARED TO UPFRONT RADICAL CYSTECTOMY IN BCG-UNRESPONSIVE NON-MUSCLE INVASIVE BLADDER CANCER
Annapureddy D, Taylor J, Howard J, Woldu S, Lotan Y, Tan W, Kamat A, McElree I, Packiam V, O'Donnell M, Facundo D, Li R, Yim K, Preston M, Harrington S, Dyer E, Raman J, Black A, Black P, Kanabur P, Lerner S, Roumiguié M, Steinberg G, Huang W. ONCOLOGIC OUTCOMES OF GEMCITABINE-DOCETAXEL COMBINATION INTRAVESICAL BLADDER SPARING THERAPY COMPARED TO UPFRONT RADICAL CYSTECTOMY IN BCG-UNRESPONSIVE NON-MUSCLE INVASIVE BLADDER CANCER. Urologic Oncology Seminars And Original Investigations 2024, 42: s52-s53. DOI: 10.1016/j.urolonc.2024.01.160.Peer-Reviewed Original ResearchNon-muscle invasive bladder cancerBladder-sparing therapyBCG-unresponsive diseaseBCG-unresponsive NMIBCMultinational cohort of patientsUpfront RCCancer-specific survivalInvasive bladder cancerRadical cystectomyOncological outcomesCohort of patientsAdequate BCGBCG therapyBCG-unresponsiveSalvage therapySpecific survivalBladder cancerMultinational cohortBCG-unresponsive NMIBC patientsAdequate BCG therapyBladder sparing therapyCombination intravesical therapyMaintenance BCG therapyNode positivity rateCompare oncologic outcomesNATURAL HISTORY OF BLADDER-SPARING THERAPY IN PATIENTS WITH BCG-UNRESPONSIVE DISEASE; RESULTS FROM A LARGE MULTI-CENTER COHORT
Taylor J, Annapureddy D, Howard J, Woldu S, Lotan Y, Tan W, Kamat A, McElree I, Packiam V, O'Donnell M, Davaro F, Li R, Yim K, Preston M, Harrington S, Dyer E, Raman J, Black A, Black P, Kanabur P, Lerner S, Roumiguié M, Steinberg G, Huang W. NATURAL HISTORY OF BLADDER-SPARING THERAPY IN PATIENTS WITH BCG-UNRESPONSIVE DISEASE; RESULTS FROM A LARGE MULTI-CENTER COHORT. Urologic Oncology Seminars And Original Investigations 2024, 42: s49. DOI: 10.1016/j.urolonc.2024.01.152.Peer-Reviewed Original ResearchNon-muscle invasive bladder cancerBCG-unresponsive NMIBCBladder-sparing therapyBCG-unresponsive diseaseBCG-unresponsiveRate of cystectomyCohort of patientsOncological outcomesRadical cystectomyBladder cancer deathAdequate BCGBCG therapyOncological riskCancer deathRetrospective multi-center cohortInternational cohort of patientsAdequate BCG therapyAlternative intravesical agentsIntravesical mitomycin CMaintenance BCG therapyNatural historyUpfront radical cystectomyInferior oncologic outcomesMulti-center cohort of patientsUpper tract diseaseInfluence of lamina propria invasion extension on T1 high‐grade non‐muscle‐invasive bladder cancer in patients undergoing BCG or radical cystectomy
Contieri R, Tan W, Grajales V, Hensley P, Martini A, Bree K, Myers A, Nogueras‐Gonzalez G, Navai N, Dinney C, Guo C, Kamat A. Influence of lamina propria invasion extension on T1 high‐grade non‐muscle‐invasive bladder cancer in patients undergoing BCG or radical cystectomy. BJU International 2024, 133: 733-741. PMID: 38374533, DOI: 10.1111/bju.16293.Peer-Reviewed Original ResearchConceptsNon-muscle-invasive bladder cancerImmediate radical cystectomyCancer-specific survivalMetastasis-free survivalProgression-free survivalT1 substagingOverall survivalRadical cystectomyPathology reportsBladder cancerHigh-grade non-muscle-invasive bladder cancerPatients treated with bacillus Calmette-GuerinAssociated with poor progression-free survivalInstitutional review board-approved retrospective studyPatients treated with BCGPoor progression-free survivalLamina propriaAssociated with upstagingBCG-treated patientsCalculate overall survivalTreated with BCGKaplan-Meier methodHigh-grade patientsMultivariate Cox modelInvasive characteristics
2023
Bladder-sparing Treatment in Patients with Bacillus Calmette-Guerin–unresponsive Non–muscle-invasive Bladder Cancer: An Analysis of Long-term Survival Outcomes
Tan W, Grajales V, Contieri R, Hensley P, Bree K, Msaouel P, Guo C, Nogueras-Gonzalez G, Navai N, Dinney C, Kamat A. Bladder-sparing Treatment in Patients with Bacillus Calmette-Guerin–unresponsive Non–muscle-invasive Bladder Cancer: An Analysis of Long-term Survival Outcomes. European Urology Open Science 2023, 53: 16-22. PMID: 37441349, PMCID: PMC10334230, DOI: 10.1016/j.euros.2023.04.013.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerBladder-sparing treatmentLong-term survival outcomesCancer-specific survivalBCG-unresponsive NMIBC patientsEarly radical cystectomyRadical cystectomySurvival outcomesOverall survivalBladder cancerDelayed RCNMIBC patientsEarly RCAnalysis of long-term survival outcomesHigh-grade recurrenceProgression-free rateRecurrence-free rateMedian follow-upShort-term outcomesLong-term outcomesCurrent smoker statusCT1 diseaseLymphovascular invasionVariant histologyPrimary endpointRobot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials
Khetrapal P, Wong J, Tan W, Rupasinghe T, Tan W, Williams S, Boorjian S, Wijburg C, Parekh D, Wiklund P, Vasdev N, Khan M, Guru K, Catto J, Kelly J. Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials. European Urology 2023, 84: 393-405. PMID: 37169638, DOI: 10.1016/j.eururo.2023.04.004.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomyOpen radical cystectomyRadical cystectomyBlood lossThromboembolic eventsAssociated with better physical functionBladder cancerPositive surgical margin rateAssociated with more blood lossRisk of thromboembolic eventsHealth-related QoLQuality of life outcomesProgression-free survivalSurgical margin rateLymph node yieldRobot-assisted approachShorter operative timeShorter hospital lengthQuality of lifeRandomized controlled trialsSystematic literature searchPhysical functionWeb of ScienceNode yieldOverall survivalMP63-15 T1 SUB-STAGING IS ASSOCIATED WITH WORSE ONCOLOGICAL OUTCOMES FOR PATIENTS TREATED WITH BACILLUS CALMETTE-GUERIN OR IMMEDIATE RADICAL CYSTECTOMY.
Contieri R, Tan W, Grajales V, Bree K, Hensley P, Guo C, Navai N, Dinney C, Kamat A. MP63-15 T1 SUB-STAGING IS ASSOCIATED WITH WORSE ONCOLOGICAL OUTCOMES FOR PATIENTS TREATED WITH BACILLUS CALMETTE-GUERIN OR IMMEDIATE RADICAL CYSTECTOMY. Journal Of Urology 2023, 209: e877. DOI: 10.1097/ju.0000000000003321.15.Peer-Reviewed Original ResearchRadical cystectomyA0607 T1 substaging is associated with worse oncological outcomes for patients treated with Bacillus Calmette-Guerin or immediate radical cystectomy
Contieri R, Tan W, Grajales V, Bree K, Hensley P, Guo C, Navai N, Dinney C, Kamat A. A0607 T1 substaging is associated with worse oncological outcomes for patients treated with Bacillus Calmette-Guerin or immediate radical cystectomy. European Urology 2023, 83: s865. DOI: 10.1016/s0302-2838(23)00653-x.Peer-Reviewed Original ResearchA0722 Bacillus calmette-guerin vs immediate radical cystectomy in eau defined very high-risk non-muscle invasive bladder cancer patients
Contieri R, Hensley P, Grajales V, Tan W, Bree K, Guo C, Nogueras-Gonzalez G, Navai N, Dinney C, Kamat A. A0722 Bacillus calmette-guerin vs immediate radical cystectomy in eau defined very high-risk non-muscle invasive bladder cancer patients. European Urology 2023, 83: s1023-s1024. DOI: 10.1016/s0302-2838(23)00766-2.Peer-Reviewed Original Research
2022
A systematic review and meta-analysis on delaying surgery for urothelial carcinoma of bladder and upper tract urothelial carcinoma: Implications for the COVID19 pandemic and beyond
Leow J, Tan W, Tan W, Tan T, Chan V, Tikkinen K, Kamat A, Sengupta S, Meng M, Shariat S, Roupret M, Decaestecker K, Vasdev N, Chong Y, Enikeev D, Giannarini G, Ficarra V, Teoh J, Collaborators O. A systematic review and meta-analysis on delaying surgery for urothelial carcinoma of bladder and upper tract urothelial carcinoma: Implications for the COVID19 pandemic and beyond. Frontiers In Surgery 2022, 9: 879774. PMID: 36268209, PMCID: PMC9577485, DOI: 10.3389/fsurg.2022.879774.Peer-Reviewed Original ResearchRadical nephro-ureterectomyAssociated with poor overall survivalRadical cystectomyNeoadjuvant chemotherapyPoor overall survivalOverall survivalUrothelial carcinomaSurvival outcomesUrothelial carcinoma of bladderAssociated with poor survival outcomesUpper tract urothelial carcinomaAssociated with overall survivalDiagnosis of UCBCancer-specific survivalInvasive urothelial carcinomaCarcinoma of bladderUrologic cancer surgeryMeta-analysisPoor survival outcomesSystematic reviewDefinitive surgeryBetween-study heterogeneityDelayed surgeryNephro-ureterectomyUpper tractRobotic Intracorporeal Neobladder: UCLH Experience
Weyne E, Tan W, Kelly J, Sridhar A. Robotic Intracorporeal Neobladder: UCLH Experience. 2022, 681-686. DOI: 10.1007/978-3-031-00363-9_60.Peer-Reviewed Original ResearchRobot-assisted radical cystectomyUniversity College London HospitalRadical cystectomyBladder cancerHigh-risk non-muscle-invasive bladder cancerTreatment of muscle-invasive bladder cancerNon-muscle-invasive bladder cancerMuscle-invasive bladder cancerRobotic radical cystectomyOrthotopic continent diversionPatient selectionContinent diversionCystectomyPostoperative careOperative techniqueNeobladderOrgan‐sparing radical cystectomy: improving functional outcomes
Tan W, Ta A, Sridhar A, Kelly J. Organ‐sparing radical cystectomy: improving functional outcomes. Trends In Urology & Men's Health 2022, 13: 7-10. DOI: 10.1002/tre.875.Peer-Reviewed Original Research
2021
Defining Factors Associated with High-quality Surgery Following Radical Cystectomy: Analysis of the British Association of Urological Surgeons Cystectomy Audit
Tan W, Leow J, Marchese M, Sridhar A, Hellawell G, Mossanen M, Teoh J, Fowler S, Colquhoun A, Cresswell J, Catto J, Trinh Q, Kelly J, Section of Oncology O. Defining Factors Associated with High-quality Surgery Following Radical Cystectomy: Analysis of the British Association of Urological Surgeons Cystectomy Audit. European Urology Open Science 2021, 33: 1-10. PMID: 34723215, PMCID: PMC8546928, DOI: 10.1016/j.euros.2021.08.005.Peer-Reviewed Original ResearchMixed-effects logistic regression modelsIndex admission mortalityLogistic regression modelsHigh-quality surgeryAdmission mortalityHierarchical mixed-effects logistic regression modelsSurgeon operative volumeBritish Association of Urological SurgeonsRadical cystectomyDelivery of careRegression modelsMedian surgeonHospital operative volumeEvaluate healthcareAnnual operative volumeOperative volumePatients treated with surgical excisionComplex oncologyUK hospitalsAssociated with high morbidityOutcome measuresHospital volumeMinimally invasive approachQuality assurance programmeMinimally invasive RCPD59-10 FACTORS ASSOCIATED WITH HIGH-QUALITY SURGERY FOLLOWING RADICAL CYSTECTOMY: ANALYSIS OF THE BRITISH ASSOCIATION OF UROLOGICAL SURGEONS (BAUS) CYSTECTOMY AUDIT
Tan W, Leow J, Marchese M, Sridhar A, Hellawell G, Mossanen M, Teoh J, Fowler S, Colquhoun A, Cresswell J, Catto J, Trinh Q, Kelly J. PD59-10 FACTORS ASSOCIATED WITH HIGH-QUALITY SURGERY FOLLOWING RADICAL CYSTECTOMY: ANALYSIS OF THE BRITISH ASSOCIATION OF UROLOGICAL SURGEONS (BAUS) CYSTECTOMY AUDIT. Journal Of Urology 2021, 206: e1057-e1058. DOI: 10.1097/ju.0000000000002096.10.Peer-Reviewed Original ResearchRadical cystectomyRecovery of health‐related quality of life in patients undergoing robot‐assisted radical cystectomy with intracorporeal diversion
Abozaid M, Tan W, Khetrapal P, Baker H, Duncan J, Sridhar A, Briggs T, Selim M, Abdallah M, Elmahdy A, Elserafy F, Kelly J. Recovery of health‐related quality of life in patients undergoing robot‐assisted radical cystectomy with intracorporeal diversion. BJU International 2021, 129: 72-79. PMID: 34092021, DOI: 10.1111/bju.15505.Peer-Reviewed Original ResearchConceptsGlobal HRQoL scoreHealth-related quality of lifeRobot-assisted radical cystectomyEORTC QLQ-C30HRQoL scoresQuality of lifeSexual functionRadical cystectomyUrinary diversionIleal conduitIC patientsRecovery of health-related quality of lifeFunction scoresClavien-Dindo complicationsHealth-related qualityPhysical function scoresRehabilitation of sexual functionIntracorporeal urinary diversionLongitudinal analysisSexual function scoresEuropean Organisation for ResearchMonths follow-upEORTC QLQ-BLM30Higher sexual function scoresReturn to baselineCurrent application of the enhanced recovery after surgery protocol for patients undergoing radical cystectomy: lessons learned from European excellence centers
Albisinni S, Moschini M, Di Trapani E, Soria F, Mari A, Aziz A, Teoh J, Laukhtina E, Mori K, D’Andrea D, Carrion D, Krajewski W, Abufaraj M, Cimadamore A, Tan W, Flippot R, Khalifa J, Gonsette K, Pradere B. Current application of the enhanced recovery after surgery protocol for patients undergoing radical cystectomy: lessons learned from European excellence centers. World Journal Of Urology 2021, 40: 1317-1323. PMID: 34076754, DOI: 10.1007/s00345-021-03746-x.Peer-Reviewed Original ResearchConceptsOpioid-sparing anesthesiaRadical cystectomyERAS implementationPreoperative carbohydrate loadingEuropean expert centersImplementation of ERASBowel preparationERAS itemsRC patientsSurgery protocolExpert centersNasogastric tubeEarly mobilizationCarbohydrate loadingImplementing ERASEligibility criteriaCystectomyEnhanced recoverySurgeonsSurgeryAnesthesiologistsPatientsAnesthesiaERAS SocietyExcellence centersP0827 Defining factors associated with high-quality surgery following radical cystectomy: Analysis of the British Association of Urological Surgeons (BAUS) cystectomy audit
Tan W, Leow J, Marchese M, Sridhar A, Hellawell G, Mossanen M, Teoh J, Fowler S, Colquhoun A, Cresswell J, Catto J, Trinh Q, Kelly J. P0827 Defining factors associated with high-quality surgery following radical cystectomy: Analysis of the British Association of Urological Surgeons (BAUS) cystectomy audit. European Urology 2021, 79: s1151. DOI: 10.1016/s0302-2838(21)01202-1.Peer-Reviewed Original ResearchIs delay to radical cystectomy following BCG failure oncologically safe?
Tan W, Kelly J. Is delay to radical cystectomy following BCG failure oncologically safe? Nature Reviews Urology 2021, 18: 323-324. PMID: 33772157, DOI: 10.1038/s41585-021-00457-1.Peer-Reviewed Original Research