2007
Stroke after transient ischaemic attack: dealing in futures
Kernan WN. Stroke after transient ischaemic attack: dealing in futures. The Lancet 2007, 369: 251-252. PMID: 17258647, DOI: 10.1016/s0140-6736(07)60121-4.Peer-Reviewed Original Research
2005
Prevalence of Abnormal Glucose Tolerance Following a Transient Ischemic Attack or Ischemic Stroke
Kernan WN, Viscoli CM, Inzucchi SE, Brass LM, Bravata DM, Shulman GI, McVeety JC. Prevalence of Abnormal Glucose Tolerance Following a Transient Ischemic Attack or Ischemic Stroke. JAMA Internal Medicine 2005, 165: 227-233. PMID: 15668371, DOI: 10.1001/archinte.165.2.227.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overBlood GlucoseCohort StudiesFemaleGlucose IntoleranceGlucose Tolerance TestHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedOdds RatioPrevalenceProbabilityPrognosisProspective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionStrokeConceptsTransient ischemic attackDiabetic glucose toleranceImpaired glucose toleranceAbnormal glucose tolerancePlasma glucose levelsRecent transient ischemic attackGlucose toleranceIschemic strokeGlucose levelsIschemic attackPhysician-diagnosed diabetes mellitusOral glucose tolerance testStepwise logistic regression modelIncident vascular diseaseRecurrent brain diseaseVascular disease mortalityHistory of diabetesClinical Research CenterGlucose tolerance testLower waist circumferencePlasma glucose valuesForward stepwise logistic regression modelLogistic regression modelsEligible patientsAntihyperglycemic therapy
2001
A Quality-of-Life Instrument for Young Hemorrhagic Stroke Patients
Hamedani A, Wells C, Brass L, Kernan W, Viscoli C, Maraire J, Awad I, Horwitz R. A Quality-of-Life Instrument for Young Hemorrhagic Stroke Patients. Stroke 2001, 32: 687-695. PMID: 11239188, DOI: 10.1161/01.str.32.3.687.Peer-Reviewed Original ResearchConceptsOutcome measuresHemorrhagic strokeQuality of lifeValid QOL instrumentHemorrhagic stroke patientsHemorrhagic stroke survivorsAvailable outcome measuresDistinct subject groupsYounger patientsStroke patientsPatient interviewsNeurological impairmentStroke survivorsMotor functionQOL instrumentsLife instrumentsMortality ratePatient's lifeHigh initial mortality rateStrokePatientsCeiling effectsSubject groupsInitial mortality rateInternal consistency
2000
The Stroke Prognosis Instrument II (SPI-II)
Kernan W, Viscoli C, Brass L, Makuch R, Sarrel P, Roberts R, Gent M, Rothwell P, Sacco R, Liu R, Boden-Albala B, Horwitz R. The Stroke Prognosis Instrument II (SPI-II). Stroke 2000, 31: 456-462. PMID: 10657422, DOI: 10.1161/01.str.31.2.456.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHumansIschemic Attack, TransientMaleMiddle AgedPredictive Value of TestsPrognosisStrokeConceptsRisk groups ICongestive heart failurePooled rateRisk groupsGroup IPrior strokeSPI-IIHeart failureOutcome ratesTest cohortPooled outcome ratesTransient ischemic attackCoronary artery diseasePatient risk groupsStroke Prognosis Instrument IIReceiver operator characteristic analysisOperator characteristic analysisIschemic attackIschemic strokeArtery diseaseIndex eventPatient counselingNew predictive variablesStrokeTotal score
1999
Stratified Randomization for Clinical Trials
Kernan W, Viscoli C, Makuch R, Brass L, Horwitz R. Stratified Randomization for Clinical Trials. Journal Of Clinical Epidemiology 1999, 52: 19-26. PMID: 9973070, DOI: 10.1016/s0895-4356(98)00138-3.Peer-Reviewed Original ResearchConceptsStratified randomizationSmall trialsInterim analysisActive-control equivalence trialsClinical factorsLarge trialsSuperiority trialSubgroup analysisClinical trialsTreatment responsivenessTreatment outcomesMEDLINE searchTreatment groupsStratification factorsEquivalence trialPrognosisTrialsRandomizationType ITheoretical benefitsImportance of stratificationStratificationSample sizeInvestigatorsPatients
1991
A methodological appraisal of research on prognosis after transient ischemic attacks.
Kernan W, Feinstein A, Brass L. A methodological appraisal of research on prognosis after transient ischemic attacks. Stroke 1991, 22: 1108-1116. PMID: 1926253, DOI: 10.1161/01.str.22.9.1108.Peer-Reviewed Original ResearchConceptsTransient ischemic attackTransient ischemiaIschemic attackEligible studiesAspects of prognosisObservational cohort studyPrognosis of patientsSubgroup of patientsAppropriate end pointsPeer-reviewed journalsCohort studyInception cohortOutcome ratesIndividual patientsDiagnostic criteriaPatientsOutcome riskIschemiaMultivariate analysisPrognosisEnd pointSubsequent strokeAdherencePredictive variablesStrokeA prognostic system for transient ischemia or minor stroke.
Kernan WN, Horwitz RI, Brass LM, Viscoli CM, Taylor KJ. A prognostic system for transient ischemia or minor stroke. Annals Of Internal Medicine 1991, 114: 552-7. PMID: 2001088, DOI: 10.7326/0003-4819-114-7-552.Peer-Reviewed Original ResearchConceptsCarotid transient ischemic attacksTransient ischemic attackMinor strokeOutcome ratesRisk group 1Ischemic attackTransient ischemiaPrognostic systemGroup 1Urban community teaching hospitalInception cohort studyCommunity teaching hospitalEligible patientsCohort studyClinical featuresOriginal cohortTeaching hospitalTest cohortStrokePatientsSubsequent strokeHypertensionIschemiaDeathDiabetes