1985
Cross-linking studies with the uvrA and uvrB proteins of E. coli
Strike P, Rupp W. Cross-linking studies with the uvrA and uvrB proteins of E. coli. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1985, 145: 43-48. PMID: 3156273, DOI: 10.1016/0167-8817(85)90038-0.Peer-Reviewed Original Research
1983
A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region
Sancar A, Rupp W. A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region. Cell 1983, 33: 249-260. PMID: 6380755, DOI: 10.1016/0092-8674(83)90354-9.Peer-Reviewed Original ResearchConceptsUvrABC nucleaseFifth phosphodiester bond 3Escherichia coliDNA strandsPhosphodiester bond 3UvrABC excision nucleasePyrimidine dimersUV-induced mutagenesisUvrC proteinUV-irradiated DNAExcision nucleaseRepair enzymesPhosphodiester bondNucleaseEnzymeProteinBond 3DNAColiUvrBStrandsUvrAMutagenesisDimersSame mechanism
1982
LexA protein inhibits transcription of the E. coli uvrA gene in vitro
Sancar A, Sancar G, Rupp W, Little J, Mount D. LexA protein inhibits transcription of the E. coli uvrA gene in vitro. Nature 1982, 298: 96-98. PMID: 6283374, DOI: 10.1038/298096a0.Peer-Reviewed Original ResearchThe uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoters
Sancar G, Sancar A, Little J, Rupp W. The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoters. Cell 1982, 28: 523-530. PMID: 6280873, DOI: 10.1016/0092-8674(82)90207-0.Peer-Reviewed Original ResearchConceptsRepressor-operator complexUvrB geneEscherichia coliLexA binding siteBinding of LexALexA proteinInhibits transcriptionRNA polymerasePribnow boxTranscriptionP3 promoterThird promoterPromoterPhysiological significanceLexABinding sitesGenesDetectable effectColiUvrBComplexesPolymeraseGTPNucleotidesProtein
1981
E. coli uvrB protein binds to DNA in the presence of uvrA protein
Kacinski B, Rupp W. E. coli uvrB protein binds to DNA in the presence of uvrA protein. Nature 1981, 294: 480-481. PMID: 6273745, DOI: 10.1038/294480a0.Peer-Reviewed Original ResearchConceptsGene productsMulti-protein complexesUvrC gene productDNA-binding proteinsNucleotide excision repairPresence of UvrAUvrA proteinEndonucleolytic incisionProtein bindsExcision repairUvrBUvrADNADirect interactionProteinBulky lesionsPyrimidine dimersGenesTight bindingBindsBindingRepairEarly stagesVivoPurification