2021
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2
Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metabolism 2021, 33: 2277-2287.e5. PMID: 34473956, PMCID: PMC9067336, DOI: 10.1016/j.cmet.2021.08.004.Peer-Reviewed Original ResearchConceptsOld miceType 2 innate lymphoid cellsInnate lymphoid cellsTissue-resident cellsCore body temperatureAdoptive transferIL-33ILC2 numbersTissue inflammationAged miceImmunometabolic responsesMetabolic impairmentLymphoid cellsDietary restrictionImmune systemILC2Functional defectsMiceBody temperatureFailureCellsInflammationTranscriptomic analysisInfectionStress responseKetogenic diet restrains aging-induced exacerbation of coronavirus infection in mice
Ryu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. ELife 2021, 10: e66522. PMID: 34151773, PMCID: PMC8245129, DOI: 10.7554/elife.66522.Peer-Reviewed Original ResearchConceptsΓδ T cellsKetogenic dietCoronavirus infectionAged miceT cellsHigher systemic inflammationInfected aged miceCOVID-19 severityCOVID-19 infectionActivation of ketogenesisMouse hepatitis virus strain A59Systemic inflammationInflammatory damageInfluenza infectionClinical hallmarkNLRP3 inflammasomeImmune surveillanceAdipose tissuePotential treatmentInfectionMiceStrongest predictorLungMortalityAge
2019
AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS
Camell C, Dixit V. AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS. Innovation In Aging 2019, 3: s106-s106. PMCID: PMC6845598, DOI: 10.1093/geroni/igz038.397.Peer-Reviewed Original ResearchFat-associated lymphoid clustersTissue B cellsB cell expansionAdipose tissueB cellsNLRP3 inflammasomeAdipose tissue immune cellsVisceral white adipose tissueB cell profileB-cell depletionB cell accumulationTissue immune cellsVisceral adipose tissueWhite adipose tissueAged B cellsFALC formationVisceral adiposityCell depletionInduces NLRP3Aged miceImmune cellsInsulin sensitivityFemale miceLymphoid clustersMetabolic dysfunction
2017
NLRP3 Inflammasome controls adipose tissue macrophage activation during aging
Camell C, Sander J, Spadaro O, Lee A, Nguyen K, Wing A, Goldberg E, Youm Y, Rodeheffer M, Schultze J, Dixit V. NLRP3 Inflammasome controls adipose tissue macrophage activation during aging. The Journal Of Immunology 2017, 198: 154.3-154.3. DOI: 10.4049/jimmunol.198.supp.154.3.Peer-Reviewed Original ResearchAge-related inflammationMacrophage activationAT macrophagesImmune-metabolic interactionsCaspase-1 activationAdipose tissue homeostasisAge-related defectsAT inflammationOld WTVisceral adiposityImmune defectsChronic inflammationInsulin resistanceAged miceImmune populationsImmune cellsInflammatory responseMetabolic dysfunctionAge-induced changesMacrophage subsetsMultiple organsInflammationNLRP3Tissue macrophagesDegenerative disorders
2015
NLRP3 inflammasome controls adipose tissue leukocytosis and inflammation during aging (INM6P.331)
Camell C, Youm Y, Nguyen K, Ravussin A, Spadaro O, Dixit V. NLRP3 inflammasome controls adipose tissue leukocytosis and inflammation during aging (INM6P.331). The Journal Of Immunology 2015, 194: 193.5-193.5. DOI: 10.4049/jimmunol.194.supp.193.5.Peer-Reviewed Original ResearchAge-related inflammationAdipose tissueAged miceAntigen-specific T cellsDistinct inflammatory signatureB cell infiltrationSpecific T cellsOld control miceVisceral adipose tissueIL-1β signalingB cell subpopulationsAT inflammationAT macrophagesInflammatory signatureVisceral adiposityImmune defectsChronic inflammationControl miceInsulin resistanceLymphocyte clustersCell infiltrationImmune cellsMetabolic dysfunctionT cellsAge-induced changesKetone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153)
Goldberg E, Youm Y, Nguyen K, Alnemri E, Dixit V. Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153). The Journal Of Immunology 2015, 194: 48.10-48.10. DOI: 10.4049/jimmunol.194.supp.48.10.Peer-Reviewed Original ResearchBeta-hydroxy butyrateInflammasome activationMyeloid cellsNLRP3-dependent inflammasome activationAnti-inflammatory interventionsNLRP3-dependent ILMyeloid lineage cellsShort-chain fatty acidsDependent inflammasome activationKetone body productionFatty acid oxidationBone lossChronic inflammationAge-related diseasesAged miceNLRP3 inflammasomeSterile inflammationChronic diseasesFunctional declineMetabolic diseasesCognitive declineCalorie restrictionChain fatty acidsInflammationLineage cells