2023
Aberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity
Hauke D, Charlton C, Schmidt A, Griffiths J, Woods S, Ford J, Srihari V, Roth V, Diaconescu A, Mathalon D. Aberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 8: 1176-1185. PMID: 37536567, DOI: 10.1016/j.bpsc.2023.07.011.Peer-Reviewed Original ResearchConceptsPrecision-weighted prediction errorsHealthy control participantsCourse of schizophreniaCHR-P individualsLower-level precision-weighted prediction errorsControl participantsLow-level sensoryPredictive coding accountMismatch negativity paradigmHierarchical Gaussian FilterPrediction errorEarly psychosisSingle-trial analysisClinical high riskDouble deviantsMismatch negativityComputational mechanismsElectroencephalography amplitudeFuture psychosisComputational modelSchizophreniaPsychosisIndividualsParticipantsSensor space
2018
Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300
Hamilton HK, Woods SW, Roach BJ, Llerena K, McGlashan TH, Srihari VH, Ford JM, Mathalon DH. Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300. Schizophrenia Bulletin 2018, 45: 1068-1080. PMID: 30753731, PMCID: PMC6737543, DOI: 10.1093/schbul/sby167.Peer-Reviewed Original ResearchConceptsPsychosis risk syndromeTarget P3bProcessing deficitsPsychosis onsetEvent-related potential componentP300 event-related potential componentTarget P3b amplitudesPsychosis riskInfrequent target stimuliVisual oddball taskPRS participantsHealthy control participantsP3b amplitudeVisual modalityTarget stimuliP3a amplitudeSchizophrenia participantsOddball taskNovel stimuliP300 amplitudeHC participantsRisk syndromeP3bVulnerability markerControl participants
2017
Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders
Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry 2017, 81: 848-861. PMID: 28434615, PMCID: PMC5436134, DOI: 10.1016/j.biopsych.2017.03.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutism Spectrum DisorderBrainElectroencephalographyHumansMagnetic Resonance ImagingMagnetoencephalographyNeural InhibitionSchizophreniaConceptsAutism spectrum disorderSpectrum disorderFunctional magnetic resonance imagingRecent theoretical accountsEarly course schizophreniaNeurodevelopmental disordersPharmacological challenge studiesNeural correlatesNeuroscience literatureTheoretical accountsNeural circuitryTheoretical neuroscienceNoninvasive neuroimagingBehavioral dysfunctionFuture researchNeuropsychiatric conditionsComputational modelSchizophreniaProton magnetic resonance spectroscopyDisordersInhibition imbalanceMagnetic resonance imagingDistinct modalitiesPoint of convergenceInhibition balance
2015
Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients
Hay RA, Roach BJ, Srihari VH, Woods SW, Ford JM, Mathalon DH. Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients. Biological Psychology 2015, 105: 130-137. PMID: 25603283, PMCID: PMC4336819, DOI: 10.1016/j.biopsycho.2015.01.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleSchizophreniaYoung AdultConceptsSchizophrenia spectrum patientsHealthy controlsEarly schizophrenia patientsMMN amplitude reductionDuration of illnessCourse of schizophreniaMismatch negativityDeviant typesMismatch negativity deficitsClinical symptomsDifferent deviant typesNeurophysiological abnormalitiesAuditory deviantsSchizophrenia patientsPatientsAuditory deviance processingIllnessNeurophysiological mechanismsAmplitude reductionSignificant interactionMMN responsesDeviance processingSymptomsAbnormalitiesSchizophrenia
2013
Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia
Perez VB, Roach BJ, Woods SW, Srihari VH, McGlashan TH, Ford JM, Mathalon DH. Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia. Supplements To Clinical Neurophysiology 2013, 62: 147-162. PMID: 24053038, PMCID: PMC4120874, DOI: 10.1016/b978-0-7020-5307-8.00010-7.Peer-Reviewed Original ResearchConceptsClinical high riskPhase-locking factorGamma-band responseAuditory gamma-band responsesCHR patientsHigh riskSchizophrenia patientsChronic schizophrenia patientsNMDA glutamate receptorsYounger schizophrenia patientsTransient gamma-band responseTrend-level reductionsNeurotransmission abnormalitiesGamma-band oscillationsYounger patientsIllness onsetProdromal symptomsPhase synchronyProdromal periodHealthy controlsPsychosis onsetPatientsPsychotic disordersCHR groupElectroencephalographic studies