2015
First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial
Srihari VH, Tek C, Kucukgoncu S, Phutane VH, Breitborde NJ, Pollard J, Ozkan B, Saksa J, Walsh BC, Woods SW. First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial. Psychiatric Services 2015, 66: 705-712. PMID: 25639994, PMCID: PMC4490067, DOI: 10.1176/appi.ps.201400236.Peer-Reviewed Original ResearchConceptsUsual treatmentSTEP participantsCommunity mental health centerFirst-episode servicesFirst-episode psychosisMental health centersSerious mental illnessInpatient psychiatric unitAntipsychotic exposureAdditional patientsIllness onsetHospital utilizationHealth centersInpatient utilizationPsychiatric hospitalizationMAIN OUTCOMEPsychotic illnessPsychiatric unitPsychotic disordersHospitalizationEarly interventionMental illnessSpecialized treatmentPatientsTranslational research
2014
Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study
Srihari VH, Tek C, Pollard J, Zimmet S, Keat J, Cahill JD, Kucukgoncu S, Walsh BC, Li F, Gueorguieva R, Levine N, Mesholam-Gately RI, Friedman-Yakoobian M, Seidman LJ, Keshavan MS, McGlashan TH, Woods SW. Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study. BMC Psychiatry 2014, 14: 335. PMID: 25471062, PMCID: PMC4262386, DOI: 10.1186/s12888-014-0335-3.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health CareEarly DiagnosisHealth Services Needs and DemandHumansPsychotic DisordersTime FactorsTreatment OutcomeUnited StatesConceptsEarly detectionEarly outcomesGeographic catchmentTIPS studyYounger patientsAppropriate patientsUntreated psychosisPsychosis onsetEffective treatmentCare providersPsychotic symptomsPublic education campaignsPsychotic disordersHelp-seeking behaviorSecondary aimComprehensive interventionPatientsIntervention servicesDUPEducation campaignsOutcomesSocial marketing approachPrimary aimTreatmentFESThe impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: A double-blind, randomized, placebo-controlled trial
Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: A double-blind, randomized, placebo-controlled trial. Schizophrenia Research 2014, 160: 180-185. PMID: 25454802, PMCID: PMC5589464, DOI: 10.1016/j.schres.2014.10.002.Peer-Reviewed Original ResearchMeSH KeywordsAzabicyclo CompoundsCognitionDouble-Blind MethodEszopicloneFemaleHumansHypnotics and SedativesMaleMedical RecordsMiddle AgedPatient DropoutsPiperazinesPsychotic DisordersQuality of LifeSchizophreniaSchizophrenic PsychologySingle-Blind MethodSleepSleep Initiation and Maintenance DisordersTreatment OutcomeConceptsInsomnia Severity IndexSingle-blind placebo phasePlacebo phaseOutcome measuresPsychiatric symptomsPlacebo-controlled trialDouble-blind placeboSecondary outcome measuresPrimary outcome measureEffects of eszopicloneBetween-group differencesTreatment of insomniaQuality of lifeDiscontinuation ratesMATRICS Consensus Cognitive BatteryStable outpatientsConsensus Cognitive BatterySchizoaffective disorderCognitive impairmentSleep diaryPatientsInsomniaScore changeEszopiclonePlacebo
2012
Is Early Intervention for Psychosis Feasible and Effective?
Srihari VH, Shah J, Keshavan MS. Is Early Intervention for Psychosis Feasible and Effective? Psychiatric Clinics Of North America 2012, 35: 613-631. PMID: 22929869, PMCID: PMC3431510, DOI: 10.1016/j.psc.2012.06.004.Peer-Reviewed Original Research
2009
Cognitive Behavior Therapy for Early Psychosis: A Comprehensive Review of Individual vs. Group Treatment Studies
Saksa JR, Cohen SJ, Srihari VH, Woods SW. Cognitive Behavior Therapy for Early Psychosis: A Comprehensive Review of Individual vs. Group Treatment Studies. International Journal Of Group Psychotherapy 2009, 59: 357-383. PMID: 19548785, DOI: 10.1521/ijgp.2009.59.3.357.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyHumansPsychotherapy, GroupPsychotic DisordersSchizophreniaSeverity of Illness IndexTreatment OutcomeConceptsGroup cognitive behavior therapyCognitive behavior therapyEarly psychosisEarly casesModest treatment benefitsGroup of patientsBehavior therapyYounger patientsGroup treatment studyTreatment benefitPatient uncertaintyEffective modalityTreatment studiesPsychosisPatientsTherapyOutcomesRecent studiesCurrent studyIllnessComprehensive review
2008
Successful acamprosate treatment of alcohol dependence in schizophrenia
Tek C, Srihari V, Tek E. Successful acamprosate treatment of alcohol dependence in schizophrenia. Schizophrenia Research 2008, 106: 373. PMID: 18804961, DOI: 10.1016/j.schres.2008.08.010.Peer-Reviewed Original Research