Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder
Goetzl EJ, Wolkowitz OM, Srihari VH, Reus VI, Goetzl L, Kapogiannis D, Heninger GR, Mellon SH. Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder. Molecular Psychiatry 2021, 26: 7355-7362. PMID: 34471251, PMCID: PMC8872999, DOI: 10.1038/s41380-021-01268-x.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesMitochondrial proteinsCyclophilin DMitofusin 2Extracellular vesiclesFunctional mitochondrial proteinsElectron transport complexes INuclear respiratory factorOpen-reading frameNeuronal extracellular vesiclesNew drug targetsΓ coactivator 1αPenultimate enzymeTranscription factorsMajor depressive disorderLeucine zipperMyosin VIGene responsesMitochondrial biogenesisPotential biomarker proteinsProtein componentsSelective serotonin reuptake inhibitorsPPAR-γ coactivator 1αComplex IDrug targetsNeural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis
Goetzl EJ, Srihari VH, Guloksuz S, Ferrara M, Tek C, Heninger GR. Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis. The FASEB Journal 2021, 35: e21339. PMID: 33454965, DOI: 10.1096/fj.202002519r.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesFunctional proteinsMitochondrial functional proteinsMitochondrial protein mitofusin 2Extracellular vesiclesMitochondrial ATP synthaseMitochondrial ATP synthase activityATP synthase activityTranscription factor AMitochondrial proteinsATP synthaseMyosin VICyclophilin DConversion of NADHMitofusin 2EV contentExosome markersPeptide humaninProteinMitochondrial impairmentSynthase activityProtein levelsFactor AMitochondriaVesicles