2024
Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia
Lee S, Benson J, Cohen A, Quagliarello V, Juthani-Mehta M, Datta R. Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia. Antimicrobial Stewardship & Healthcare Epidemiology 2024, 4: e48. PMID: 38655023, PMCID: PMC11036428, DOI: 10.1017/ash.2024.54.Peer-Reviewed Original ResearchNon-ventilator hospital-acquired pneumoniaAdvanced cancerPalliative care settingHospital-acquired pneumoniaCohort study of patientsCare settingsOlder adultsAdjusted oddsDuration of antibiotic therapyAssociated with reduced adjusted oddsSingle-center observational studyCohort studyProlonged antibiotic durationObservational studyStudy of patientsAntimicrobial stewardship effortsAntibiotic durationAntibiotic therapyStewardship effortsPneumoniaCancerOddsReadmissionAdultsCohort
2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer
Lee S, O’Donovan L, Cohen A, Gautam S, Quagliarello V, Juthani-Mehta M, Datta R. Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer. Antimicrobial Stewardship & Healthcare Epidemiology 2022, 2: e152. PMID: 36483405, PMCID: PMC9726473, DOI: 10.1017/ash.2022.293.Peer-Reviewed Original Research
2020
Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey
Datta R, Topal J, McManus D, Sanft T, Dembry LM, Morrison LJ, Quagliarello V, Juthani-Mehta M. Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey. Palliative Medicine 2020, 35: 236-241. PMID: 32928066, DOI: 10.1177/0269216320956811.Peer-Reviewed Original ResearchConceptsEscalation of careAdvance care planningLife careAdvanced cancerCross-sectional surveyIntravenous antimicrobialsOlder adultsAntimicrobial useCare planningSingle-center cross-sectional surveyEducational interventionAdvance care plansRole of antimicrobialsClinical deteriorationPercent of respondentsAdverse eventsOral antimicrobialsMedicine subspecialistsCare plansInpatient medicineCareCancerPatientsAdultsSubspecialists
2015
The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases
Zapata HJ, Quagliarello VJ. The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases. Journal Of The American Geriatrics Society 2015, 63: 776-781. PMID: 25851728, PMCID: PMC4406803, DOI: 10.1111/jgs.13310.Peer-Reviewed Original ResearchConceptsOlder adultsClostridium difficile colitisDevelopment of comorbiditiesCommensal bacterial communityDifficile colitisVulvovaginal atrophyProinflammatory stateAtherosclerotic diseaseClinical changesColorectal carcinomaPhysical frailtyClinical problemLocation of residenceGut microbiotaDeoxyribonucleic acid sequencingHealthy adultsAccompany agingBasal levelsAdultsMicrobiotaDiseaseMicrobiomeColitisComorbiditiesPotential implications
2009
Bronchitis and Pneumonia
Juthani-Mehta M, Quagliarello V. Bronchitis and Pneumonia. Infectious Disease 2009, 81-95. PMCID: PMC7121308, DOI: 10.1007/978-1-60327-534-7_7.Peer-Reviewed Original ResearchOlder adultsOral hygieneLong-term care residentsPoor oral hygieneChest X-rayLack of vaccinationSite of careUnique risk factorsEmpirical treatment decisionsMultiple comorbiditiesClinical entityClinical manifestationsMental statusRisk factorsHome therapyHome residentsTreatment decisionsCare residentsCommunity dwellersPneumoniaBetter outcomesNursing homesPrevention strategiesBronchitisAdults
2006
Short- and Long-term Functional Outcome of Hospitalized Older Adults With Community-acquired Pneumonia
Sharma G, Han L, Quagliarello V. Short- and Long-term Functional Outcome of Hospitalized Older Adults With Community-acquired Pneumonia. Infectious Diseases In Clinical Practice 2006, 14: 365-368. DOI: 10.1097/01.idc.0000227715.26754.e7.Peer-Reviewed Original ResearchCommunity-acquired pneumoniaMonths postdischargeFunctional outcomeLong-term functional outcomeElderly patientsADL declineMean ADLMean ageInclusion criteriaFunctional declineDaily livingPostdischargeElderly adultsPatientsOlder adultsCollected databaseMonthsHospitalizationPneumoniaPotential subjectsAdultsOutcomesIllnessADLDecline
2004
Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults
High K, Juthani-Mehta M, Quagliarello V. Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults. Clinical Infectious Diseases 2004, 38: 692-696. PMID: 14986254, DOI: 10.1086/381688.Peer-Reviewed Original ResearchConceptsPrognostic scoring systemOlder adultsScoring systemAdult populationInfectious diseasesPrimary end pointNumber of patientsGeneral adult populationHealth care needsHealth care costsHeterogeneous adult populationClinical outcomesBloodstream infectionsIndividual patientsCare needsCare costsRelevant outcomesEnd pointClinical predictionDiseasePatientsAdultsFurther investigationCareOutcomes
2001
Community-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death
McMillan D, Lin C, Aronin S, Quagliarello V. Community-Acquired Bacterial Meningitis in Adults: Categorization of Causes and Timing of Death. Clinical Infectious Diseases 2001, 33: 969-975. PMID: 11528567, DOI: 10.1086/322612.Peer-Reviewed Original ResearchConceptsCommunity-acquired bacterial meningitisBacterial meningitisTiming of deathImmediate causeSurvival end pointsWorld Health OrganizationMeningitisHealth StatisticsEnd pointUnderlying causeCategorization of causesHealth OrganizationDeathSubstantial proportionCategory IIIPatientsCategory IIAdultsCauseCategory IHospitalizationUtility of prognostic stratification in adults with community-acquired bacterial meningitis
Aronin S, Quagliarello V. Utility of prognostic stratification in adults with community-acquired bacterial meningitis. Comprehensive Therapy 2001, 27: 72-77. PMID: 11280860, DOI: 10.1007/s12019-001-0011-7.Peer-Reviewed Original Research
1993
Group B Streptococcal Meningitis in Adults
DUNNE D, QUAGLIARELLO V. Group B Streptococcal Meningitis in Adults. Medicine 1993, 72: 1-10. PMID: 8426534, DOI: 10.1097/00005792-199301000-00001.Peer-Reviewed Original ResearchConceptsGroup B streptococcal meningitisStreptococcal meningitisPercent of patientsCo-morbid illnessHours of symptomsBimodal age distributionConcomitant bacteremiaUnderlying illnessGBS infectionUncommon causeImmunocompromised hostOverall mortalityClinical presentationPyogenic organismsAdult casesRetrospective analysisMeningitisFrequent entityPatientsAdultsIllnessAge distributionHigh percentageBacteremiaImmunocompetent