2019
Spatiotemporal dynamics of odor responses in the lateral and dorsal olfactory bulb
Baker KL, Vasan G, Gumaste A, Pieribone VA, Verhagen JV. Spatiotemporal dynamics of odor responses in the lateral and dorsal olfactory bulb. PLOS Biology 2019, 17: e3000409. PMID: 31532763, PMCID: PMC6768483, DOI: 10.1371/journal.pbio.3000409.Peer-Reviewed Original Research
2018
Fast, in vivo voltage imaging using a red fluorescent indicator
Kannan M, Vasan G, Huang C, Haziza S, Li JZ, Inan H, Schnitzer MJ, Pieribone VA. Fast, in vivo voltage imaging using a red fluorescent indicator. Nature Methods 2018, 15: 1108-1116. PMID: 30420685, PMCID: PMC6516062, DOI: 10.1038/s41592-018-0188-7.Peer-Reviewed Original ResearchConceptsOptical toolsOptical toolboxUnparalleled temporal resolutionRed fluorescent indicatorVoltage imagingOptical electrophysiologyModest illumination intensitiesHigh-throughput strategyVoltage indicatorsIllumination intensityNew hueAcute brain slicesMultispectral imagingGreen probesSubthreshold voltageTemporal resolutionEnhanced sensitivityPostsynaptic potentialsMRuby3Brain slicesHippocampal rhythmsActivity monitorFunctional imagingImagingGEVIs
2017
Optimizing recruitment and retention of adolescents in ED research: Findings from concussion biomarker pilot study
Mbachu SN, Pieribone VA, Bechtel KA, McCarthy ML, Melnick ER. Optimizing recruitment and retention of adolescents in ED research: Findings from concussion biomarker pilot study. The American Journal Of Emergency Medicine 2017, 36: 884-887. PMID: 28918968, DOI: 10.1016/j.ajem.2017.09.014.Peer-Reviewed Original Research
2016
A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices
Abdelfattah AS, Farhi SL, Zhao Y, Brinks D, Zou P, Ruangkittisakul A, Platisa J, Pieribone VA, Ballanyi K, Cohen AE, Campbell RE. A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices. Journal Of Neuroscience 2016, 36: 2458-2472. PMID: 26911693, PMCID: PMC4764664, DOI: 10.1523/jneurosci.3484-15.2016.Peer-Reviewed Original ResearchConceptsVoltage indicatorsBlue-shifted channelrhodopsinRed-shifted fluorescent proteinsFluorescent voltage indicatorsWide-field fluorescence microscopyBlue excitationOptical imagingOptical electrophysiologyLow phototoxicityAutofluorescent backgroundLight photoactivationSingle-trial recordingsTemporal resolutionChannelrhodopsinIntrinsic advantagesExcitationVoltage oscillationsFluorescence microscopyOscillationsGreen indicatorsChromophoreMicroscopyResolution
2008
Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus
Kao H, Li P, Chao HM, Janoschka S, Pham K, Feng J, Mcewen BS, Greengard P, Pieribone VA, Porton B. Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. The Journal Of Comparative Neurology 2008, 507: 1860-1870. PMID: 18271024, DOI: 10.1002/cne.21643.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsBiomarkersCell DifferentiationCell ProliferationCell SurvivalDentate GyrusDNA-Binding ProteinsFemaleFluorescent Antibody TechniqueIntermediate Filament ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutNerve Growth FactorsNerve Tissue ProteinsNestinNeural Cell Adhesion Molecule L1Neuronal PlasticityNeuronsNuclear ProteinsSialic AcidsStem CellsSynapsinsTime FactorsTubulinConceptsHippocampal dentate gyrusWild-type miceAdult hippocampal dentate gyrusNeural progenitor cellsDentate gyrusNeural progenitor cell developmentProgenitor cellsProgenitor cell developmentSynapsin IIISynaptic vesicle-associated proteinsCell developmentSubgranular layerAdult neurogenesisKnockout miceSynaptic vesicle proteinsVesicle-associated proteinBrain regionsGyrusMiceNeurogenesisEarly involvementMarker of mitosisNovel roleVesicle proteinsProliferation
2007
Clinical Evaluation of Ganaxolone in Pediatric and Adolescent Patients with Refractory Epilepsy
Pieribone VA, Tsai J, Soufflet C, Rey E, Shaw K, Giller E, Dulac O. Clinical Evaluation of Ganaxolone in Pediatric and Adolescent Patients with Refractory Epilepsy. Epilepsia 2007, 48: 1870-1874. PMID: 17634060, DOI: 10.1111/j.1528-1167.2007.01182.x.Peer-Reviewed Original ResearchConceptsRefractory epilepsyAdverse eventsPilot studyDose escalation scheduleExtension periodDose-escalation trialEscalation scheduleSubstantial respondersAntiepileptic therapyTreat analysisGeneralized epilepsyModerate respondersAdolescent patientsClinical evaluationGanaxoloneClinical studiesPediatric subjectsPotential efficacyAnticonvulsant activityEpilepsyAdolescent subjectsOral suspensionExtension phaseDose rangeFurther studies
1994
Immunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis)
Pieribone V, Brodin L, Hökfelt T. Immunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis). The Journal Of Comparative Neurology 1994, 341: 492-506. PMID: 7515401, DOI: 10.1002/cne.903410406.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptidePeptide-immunoreactive fibersCorticotropin-releasing factorSubstance PSpinal cordImmunoreactive fibersXenopus laevis spinal cordCCK-immunoreactive fibersGene-related peptideCRF-immunoreactive fibersLabeling of fibersDouble-labeling techniqueGAL immunoreactivitySpinal transectionPeptide immunoreactivityImmunohistochemical analysisGalaninImmunohistochemical dataRostrocaudal levelsCordIntact animalsSimilar negative resultsImmunoreactive materialImmunofluorescence double-labeling techniqueCholecystokinin