2024
A multimodal Neuroimaging-Based risk score for mild cognitive impairment
Zendehrouh E, Sendi M, Abrol A, Batta I, Hassanzadeh R, Calhoun V. A multimodal Neuroimaging-Based risk score for mild cognitive impairment. NeuroImage Clinical 2024, 45: 103719. PMID: 39637673, PMCID: PMC11664180, DOI: 10.1016/j.nicl.2024.103719.Peer-Reviewed Original ResearchMild cognitive impairment riskMild cognitive impairmentMild cognitive impairment groupRisk of mild cognitive impairmentRisk scoreUK Biobank participantsFunctional network connectivityCognitive impairmentPrecursor to ADSignificant cognitive declineBiobank participantsUK BiobankMild cognitive impairment individualsGenetic risk factorsAlzheimer's diseaseFunctional MRIHigh-risk groupStructural MRIAD riskRisk factorsCognitive declineFeatures of CNGray matterDifferentiate CNParticipantsGray matters: ViT-GAN framework for identifying schizophrenia biomarkers linking structural MRI and functional network connectivity
Bi Y, Abrol A, Jia S, Sui J, Calhoun V. Gray matters: ViT-GAN framework for identifying schizophrenia biomarkers linking structural MRI and functional network connectivity. NeuroImage 2024, 297: 120674. PMID: 38851549, DOI: 10.1016/j.neuroimage.2024.120674.Peer-Reviewed Original ResearchFunctional network connectivityMedial prefrontal cortexBrain structuresFunctional network connectivity matricesPrefrontal cortexStructural MRINetwork connectivityGray matterSelf-attention mechanismGenerative adversarial networkDeep learning architectureBrain disordersDorsolateral prefrontal cortexResearch of schizophreniaNeural signal processingIdentified functional connectivityCross-domain analysisAttention mapsStructural biomarkersAdversarial networkLearning architectureDL-PFCICA algorithmSchizophrenia patientsHigh-dimensional fMRI dataSpatial Sequence Attention Network for Schizophrenia Classification from Structural Brain MR Images
Shaik N, Cherukuri T, Calhoun V, Ye D. Spatial Sequence Attention Network for Schizophrenia Classification from Structural Brain MR Images. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635528.Peer-Reviewed Original ResearchCognitive abilitiesStructural MRIAttention mechanismSchizophrenia classificationChronic mental disordersIndividual cognitive abilitiesTransfer learning paradigmDeep learning methodologyMental disordersSchizophreniaFeature mapsFeature representationConvolutional blocksAttention networkBrain MR imagesLearning paradigmSocial interactionClassification of individualsStructural brain MR imagesGray matterLearning methodologyExcitable networksClinical datasetsBrainManual observationSearching Reproducible Brain Features using NeuroMark: Templates for Different Age Populations and Imaging Modalities
Fu Z, Batta I, Wu L, Abrol A, Agcaoglu O, Salman M, Du Y, Iraji A, Shultz S, Sui J, Calhoun V. Searching Reproducible Brain Features using NeuroMark: Templates for Different Age Populations and Imaging Modalities. NeuroImage 2024, 292: 120617. PMID: 38636639, PMCID: PMC11416721, DOI: 10.1016/j.neuroimage.2024.120617.Peer-Reviewed Original ResearchConceptsFunctional MRIStructural MRIResting-state scanSpatial similarity analysisMental health researchBrain markersDiffusion MRIAge differencesBrain featuresNeuromarkersBrain disordersYoung adult cohortBrain developmentWell-replicatedHuman brainBrainDiffusion MRI dataData-driven analysisDisordersSimilarity analysisAge cohortsGeneralizabilityPopulation-based researchAdult cohortAge-specific adaptation
2023
Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics
Picci G, Ott L, Penhale S, Taylor B, Johnson H, Willett M, Okelberry H, Wang Y, Calhoun V, Stephen J, Wilson T. Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics. Human Brain Mapping 2023, 44: 6043-6054. PMID: 37811842, PMCID: PMC10619376, DOI: 10.1002/hbm.26496.Peer-Reviewed Original ResearchConceptsCortical activityRobust sex differencesFunctional brain developmentTypically-developing youthSpontaneous cortical activityLowest relative powerCortical dynamicsEndogenous testosteronePrefrontal cortexExecutive functionFrontal cortexPubertal hormonesNeural circuitryResting-stateStructural MRIEffects of testosteroneSex differencesEffects of endogenous testosteroneDevelopmental changesBrain developmentReverse patternBehavioral changesGamma activityDevelopmental windowDevelopmental patternsF71. NETWORK OF CO-METHYLATION ASSOCIATED WITH GREY MATTER MATURATION IN HUMAN ADOLESCENCE
Jensen D, Chen J, Turner J, Stephen J, Wang Y, Wilson T, Calhoun V, Liu J. F71. NETWORK OF CO-METHYLATION ASSOCIATED WITH GREY MATTER MATURATION IN HUMAN ADOLESCENCE. European Neuropsychopharmacology 2023, 75: s258-s259. DOI: 10.1016/j.euroneuro.2023.08.455.Peer-Reviewed Original ResearchStructural MRIBrain maturationNeuronal systemsCo-methylation network analysisPeriod of brain maturationAdolescent brain developmentAdolescent brain maturationPhases of neurodevelopmentIndependent component analysisGray matterHuman brain structureGM maturationDNAm changesCo-methylation modulesPrefrontal cortexExecutive functionFrontal poleGM volumeTime pointsSubjects aged 9Brain structuresCpG sitesSynaptic pruningBrain developmentDNA methylationMulti-Modal Deep Learning on Imaging Genetics for Schizophrenia Classification
Kanyal A, Kandula S, Calhoun V, Ye D. Multi-Modal Deep Learning on Imaging Genetics for Schizophrenia Classification. 2023, 00: 1-5. DOI: 10.1109/icasspw59220.2023.10193352.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsSZ patientsFunctional network connectivityFunctional MRIStructural MRIFunctional brain connectivityGenetic markersChronic mental conditionsNucleotide polymorphismsBrain connectivity featuresDecreased hippocampalGenetic featuresSZ subjectsMorphological changesThalamic volumeBrain connectivitySZ diagnosisGenetic illnessMental conditionLayer-wise relevance propagationMorphological featuresBrainConnectivity featuresSZ
2022
Deep Learning From Imaging Genetics for Schizophrenia Classification
Yu H, Florian T, Calhoun V, Ye D. Deep Learning From Imaging Genetics for Schizophrenia Classification. 2022, 00: 3291-3295. DOI: 10.1109/icip46576.2022.9897977.Peer-Reviewed Original ResearchSingle-nucleotide polymorphismsSingle nucleotide polymorphismsGenetic informationNucleotide polymorphismsGenetic changesGenetic disordersLayer-wise relevance propagationPatient's brainMorphological characteristicsPolymorphismStructural MRIMulti-modal deep learning approachExtract convolutional features