2024
Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging
Mendez Colmenares A, Thomas M, Anderson C, Arciniegas D, Calhoun V, Choi I, Kramer A, Li K, Lee J, Lee P, Burzynska A. Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging. Neurobiology Of Aging 2024, 141: 21-33. PMID: 38810596, PMCID: PMC11290458, DOI: 10.1016/j.neurobiolaging.2024.05.013.Peer-Reviewed Original ResearchDisconnection hypothesisVirginia Cognitive Aging ProjectHypothesis of cognitive agingFractional anisotropyAssociated with reduced memory performanceDeterioration of white matterAge-related memory lossPrefrontal white matterGenu of the corpus callosumMyelin water fractionVoxel-wise analysisWhite matterCorpus callosumExecutive functionCognitive agingDiffusion tensor imagingMemory performancePrefrontal WMStructural equation modelingWM microstructureAge differencesProcessing speedStructural disconnectionCognitive declineHealthy participants
2023
6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. 6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor. Journal Of The International Neuropsychological Society 2023, 29: 316-317. DOI: 10.1017/s135561772300437x.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksCognitive outcomesProcessing speedLong-term neuropsychological deficitsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingMeasures of attentionCore cognitive skillsLong-term cognitive outcomesStructural brain changesSmall-moderate effect sizeFunctional network propertiesSurvivors of brain tumorsBrain tumor survivorsGraph metricsResting state dataGlobal efficiencyNeuropsychological deficitsNeuropsychological testsBrain changesGroup differencesIndependence in adulthoodEpigenetic associations with adolescent grey matter maturation and cognitive development
Jensen D, Chen J, Turner J, Stephen J, Wang Y, Wilson T, Calhoun V, Liu J. Epigenetic associations with adolescent grey matter maturation and cognitive development. Frontiers In Genetics 2023, 14: 1222619. PMID: 37529779, PMCID: PMC10390095, DOI: 10.3389/fgene.2023.1222619.Peer-Reviewed Original ResearchGM volume increaseGray matter maturationPatterns of brain maturationImprove cognitive performanceGray matterExecutive functionEpisodic memoryCognitive performanceCognitive testsBrain structuresProcessing speedBrain maturationCognitive AssessmentCognitive scoresBrain imagingAged 9BrainEpigenetic associationsAdolescentsLongitudinal cohortDNA methylationHuman neurodevelopmentDNA methylation of genesCytosine-phosphate-guanine (CpG) sitesBrain tissueElevated C-reactive protein mediates the liver-brain axis: a preliminary study
Jiang R, Wu J, Rosenblatt M, Dai W, Rodriguez R, Sui J, Qi S, Liang Q, Xu B, Meng Q, Calhoun V, Scheinost D. Elevated C-reactive protein mediates the liver-brain axis: a preliminary study. EBioMedicine 2023, 93: 104679. PMID: 37356206, PMCID: PMC10320521, DOI: 10.1016/j.ebiom.2023.104679.Peer-Reviewed Original ResearchConceptsRegional gray matter volumeGray matter volumeCognitive functioningMost cognitive measuresUnderlying neurobiological factorsEffect sizeLarge effect sizesProspective memoryVisual memoryCognitive measuresExecutive functionTrail MakingCognitive performanceNeurobiological factorsSmall effect sizesProcessing speedVentral striatumParahippocampal gyrusCognitive declineCognitive impairmentMatter volumeMemoryFunctioningCross-sectional associationsLimited researchGraph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. Graph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor. Neuroimage Reports 2023, 3: 100178. DOI: 10.1016/j.ynirp.2023.100178.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksFunctional magnetic resonance imagingLong-term cognitive difficultiesCognitive outcomes in adulthoodCore cognitive skillsFunctional network propertiesOutcomes in adulthoodBrain tumor survivorsGraph metricsNeuroimaging researchNeuropsychological testsBrain changesCognitive difficultiesProcessing speedCognitive outcomesHub regionsSmall-worldCognitive skillsPost hoc analysisTumor survivorsPediatric brain tumor patientsSmall-world propertiesSymmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter
Colmenares A, Hefner M, Calhoun V, Salerno E, Fanning J, Gothe N, McAuley E, Kramer A, Burzynska A. Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter. Frontiers In Neurology 2023, 14: 1094313. PMID: 37139071, PMCID: PMC10149813, DOI: 10.3389/fneur.2023.1094313.Peer-Reviewed Original ResearchDiffusion tensor imagingAge differencesExamination of age differencesPattern of age differencesFractional anisotropyRadial diffusivityJoint independent component analysisCognitively healthy adultsWhite matterDiffusion tensor imaging parametersFluid abilitiesPrefrontal WMProcessing speedDiagnostic classificationWM pathologyDiffusion tensor imaging datasetsAging WMUnimodal analysisTensor imagingIndependent component analysisClinical samplesHealthy agingCognitionCorpus callosumHealthy adults