2024
Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
Sharkey R, Bacon C, Peterson Z, Rootes-Murdy K, Salvador R, Pomarol-Clotet E, Karuk A, Homan P, Ji E, Omlor W, Homan S, Georgiadis F, Kaiser S, Kirschner M, Ehrlich S, Dannlowski U, Grotegerd D, Goltermann J, Meinert S, Kircher T, Stein F, Brosch K, Krug A, Nenadic I, Sim K, Spalletta G, Banaj N, Sponheim S, Demro C, Ramsay I, King M, Quidé Y, Green M, Nguyen D, Preda A, Calhoun V, Turner J, van Erp T, Nickl-Jockschat T. Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset. Molecular Psychiatry 2024, 29: 3086-3096. PMID: 38671214, PMCID: PMC11449795, DOI: 10.1038/s41380-024-02563-z.Peer-Reviewed Original ResearchNegative FTDBrain structural changesPositive FTDSymptom dimensionsBrain regionsENIGMA Schizophrenia Working GroupNegative formal thought disorderNeural correlates of schizophreniaRegional brain volume lossFormal thought disorderSchizophrenia Working GroupCorrelates of schizophreniaLateral temporal cortexBrain volume lossThought disorderNeurobiological underpinningsNeural correlatesNeuroimaging studiesTemporal cortexSchizophreniaCortical regionsCortical thicknessCellular underpinningsFTDMulti-site cohort
2022
Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder
Qi S, Calhoun V, Zhang D, Miller J, Deng Z, Narr K, Sheline Y, McClintock S, Jiang R, Yang X, Upston J, Jones T, Sui J, Abbott C. Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder. BMC Medicine 2022, 20: 477. PMID: 36482369, PMCID: PMC9733153, DOI: 10.1186/s12916-022-02678-6.Peer-Reviewed Original ResearchConceptsMultimodal brain networksElectroconvulsive therapyBrain networksHippocampal complexCognitive impairmentSingle site clinical trialsCognitive impairing effectsSuperior orbitofrontal cortexECT seriesMedial temporal cortexLate-life depressionHDRS reductionAntidepressant outcomesOrbitofrontal cortexNeurobiological underpinningsCognitive safetyImpairing effectsTemporal cortexOptimal pulse amplitudeCognitive outcomesCognitive AssessmentCognitive-impairmentLongitudinal multimodal imagingCognitive networksDepression