2024
Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression
Thapaliya B, Ray B, Farahdel B, Suresh P, Sapkota R, Holla B, Mahadevan J, Chen J, Vaidya N, Perrone-Bizzozero N, Benegal V, Schumann G, Calhoun V, Liu J. Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression. Frontiers In Psychiatry 2024, 15: 1384298. PMID: 38827440, PMCID: PMC11141390, DOI: 10.3389/fpsyt.2024.1384298.Peer-Reviewed Original ResearchEarly life stressAdolescent anxietyLife stressMega-analysisCognitive Development StudyHypothalamic-pituitary-adrenal axisSupport IndexAssociated with anxietyRisk of anxietyExternalizing disordersAdolescent brainGenome-wide association studiesGenetic vulnerabilityAnxietyGenome-wide association analysisPublic health concernDepressionMental healthLinear mixed-effects modelsEnvironmental factorsMixed-effects modelsAssociation studiesTissue enrichment analysisGenetic associationGenomic significance
2022
Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder
Qi S, Calhoun V, Zhang D, Miller J, Deng Z, Narr K, Sheline Y, McClintock S, Jiang R, Yang X, Upston J, Jones T, Sui J, Abbott C. Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder. BMC Medicine 2022, 20: 477. PMID: 36482369, PMCID: PMC9733153, DOI: 10.1186/s12916-022-02678-6.Peer-Reviewed Original ResearchConceptsMultimodal brain networksElectroconvulsive therapyBrain networksHippocampal complexCognitive impairmentSingle site clinical trialsCognitive impairing effectsSuperior orbitofrontal cortexECT seriesMedial temporal cortexLate-life depressionHDRS reductionAntidepressant outcomesOrbitofrontal cortexNeurobiological underpinningsCognitive safetyImpairing effectsTemporal cortexOptimal pulse amplitudeCognitive outcomesCognitive AssessmentCognitive-impairmentLongitudinal multimodal imagingCognitive networksDepression