2024
Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome
Gaither J, Drago M, Grossman M, Li Y, Shabanova V, Xu X, Leventhal J. Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome. JAMA Network Open 2024, 7: e2435074. PMID: 39316398, PMCID: PMC11423163, DOI: 10.1001/jamanetworkopen.2024.35074.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeWithdrawal syndromeCohort studyHospital readmissionLow birth weightReadmission ratesRetrospective cohort studyIncreased risk of readmissionNationwide Readmissions DatabaseClinical Modification codesGestational ageOdds of readmissionMultiple gestationsFull-termInternational Classification of DiseasesRisk of readmissionHospital discharge recordsBirth weightSurvey-weighted logistic regressionType of insuranceIncreased 5-foldIncreased riskReadmissions DatabaseYear of birthState paid family leave policies and breastfeeding duration: cross-sectional analysis of 2021 national immunization survey-child
Rosenberg J, Nardella D, Shabanova V. State paid family leave policies and breastfeeding duration: cross-sectional analysis of 2021 national immunization survey-child. International Breastfeeding Journal 2024, 19: 37. PMID: 38796467, PMCID: PMC11128124, DOI: 10.1186/s13006-024-00646-9.Peer-Reviewed Original ResearchConceptsFamily leaveParental leave policiesLeave policiesSocial demographic characteristicsPolicyCross-sectional analysisUnited StatesNational Immunization Survey-ChildMedical leaveFamilyBreastfeeding ratesPromote breastfeedingSurveyed childrenStateBreastfeedingWorkforceLong-term health benefitsNationalBreastfeeding durationMixed feedPrevalence ratiosScreening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence
Adu-Gyamfi R, Enos J, Yeboah K, Shabanova V, Hawley N, Ogum D, Nkansah A, Paintsil E, Torpey K. Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence. PLOS ONE 2024, 19: e0302016. PMID: 38701070, PMCID: PMC11068165, DOI: 10.1371/journal.pone.0302016.Peer-Reviewed Original ResearchConceptsTheory-based interventionsImplementation of clinical practice guidelinesClinic visitsProvision of job aidsHealthcare workers' adherenceCluster randomized trialAvailability of guidelinesClinical practice guidelinesBehavior-based interventionsCluster-randomized studyAntiretroviral therapy sitesCardiovascular disease-related morbidityBlood pressureAIDS-related deathsIntervention facilitiesGreater Accra Region of GhanaAccra Region of GhanaGuideline adherenceHypertension screeningAntiretroviral careWorker adherenceIncidence of hypertensionHypertension riskGreater Accra RegionJob aids
2023
Diabetes in Pregnancy, Neonatal Morbidities, and Early Growth in Moderate or Late Preterm Infants.
Buck C, Shabanova V, Clark R, Taylor S. Diabetes in Pregnancy, Neonatal Morbidities, and Early Growth in Moderate or Late Preterm Infants. Pediatrics 2023, 152 PMID: 37969002, DOI: 10.1542/peds.2023-061285.Peer-Reviewed Original ResearchConceptsLate preterm infantsPreterm infantsGestational ageNeonatal morbidityBirth weightDay 14Pediatrix Clinical Data WarehouseNeonatal intensive care unitCommon neonatal morbiditiesShort-term morbidityIntensive care unitFirst postnatal dayPercent weight changeFirst postnatal weekClinical data warehouseDM groupRespiratory supportTerm morbidityCare unitDiabetes exposureAdjusted differenceCongenital anomaliesPostnatal dayHealth characteristicsPostnatal weekPediatricians' Reports of Interaction with Infant Formula Companies
Werner K, Mercurio M, Shabanova V, Hull S, Taylor S. Pediatricians' Reports of Interaction with Infant Formula Companies. Breastfeeding Medicine 2023, 18: 219-225. PMID: 36795978, DOI: 10.1089/bfm.2022.0217.Peer-Reviewed Original ResearchConceptsInfant formula companiesPercent of mothersRepresentative visitsMarketing Breast Milk SubstitutesAdvice of pediatriciansFormula companiesFree formula samplesWorld Health Organization International CodeHigh-income patientsBreast-milk substitutesHealth care staffHealth care facilitiesBreastfeeding practicesBehavior of mothersU.S. pediatriciansCare facilitiesCare staffDemographic dataPractice demographicsPediatriciansMilk substitutePrivate practiceZip codesPediatricians reportElectronic survey
2022
Does Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome?
Drago MJ, Shabanova V, Hochreiter D, Grossman M, Mercurio M. Does Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome? Maternal And Child Health Journal 2022, 26: 1095-1103. PMID: 35088297, DOI: 10.1007/s10995-021-03356-4.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeLength of stayNon-incarcerated womenLine agentsAbstinence syndromeBreast milkMean LOSLonger LOSIncarcerated womenRetrospective cohort studyFirst-line agentsMaternal-infant dyadsSecond-line agentsPrenatal substance exposurePrenatal alcohol useCare of infantsCohort studyFinnegan scoreInfant dischargeLonger hospitalizationSubstance exposureInfantsPoisson regressionMaternal incarcerationAlcohol use
2021
Preterm birth among Pacific Islander women and related perinatal outcomes: a scoping review protocol
Wu B, Arslanian KJ, Nyhan K, Taylor S, Shabanova V, Muasau-Howard B, Hawley NL. Preterm birth among Pacific Islander women and related perinatal outcomes: a scoping review protocol. BMJ Open 2021, 11: e050483. PMID: 34728448, PMCID: PMC8565552, DOI: 10.1136/bmjopen-2021-050483.Peer-Reviewed Original ResearchConceptsPreterm birthPacific IslandersMaternal-child health outcomesCause of deathPreferred Reporting ItemsJoanna Briggs Institute ManualPacific Islander womenFull-text screeningPerinatal outcomesFuture study designsPeer-reviewed journalsCochrane LibraryRisk factorsEligible studiesConsensus reviewReporting ItemsHealth outcomesReview protocolEvidence mappingStudy designEvidence synthesisBirthOutcomesScoping ReviewMinority populationsColonic Fermentation and Acetate Production in Youth with and without Obesity
Galuppo B, Cline G, Van Name M, Shabanova V, Wagner D, Kien CL, Santoro N. Colonic Fermentation and Acetate Production in Youth with and without Obesity. Journal Of Nutrition 2021, 151: 3292-3298. PMID: 34494088, PMCID: PMC8562084, DOI: 10.1093/jn/nxab277.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisLean youthLactulose ingestionGut microbiotaHepatic de novo lipogenesisDevelopment of obesityColonic acetateOral doseIntravenous infusionPeripheral circulationColonic fermentationNovo lipogenesisObesityRate of appearanceAge 15Spearman correlationIngestionLactuloseRegression modelsMicrobiotaLesser degreeComplicationsGroupInfusionFerment carbohydratesMistreatment of Providers by Patients and Family Members: Effect of an Organizational Strategy on Provider Knowledge, Self-Efficacy, and Patient Safety Incident Reporting of Mistreatment
Weiss PG, Hatfield M, Ciaburri R, Shaikh H, Wilkins KM, Bjorkman K, Goldenberg M, McCollum S, Shabanova V. Mistreatment of Providers by Patients and Family Members: Effect of an Organizational Strategy on Provider Knowledge, Self-Efficacy, and Patient Safety Incident Reporting of Mistreatment. Academic Medicine 2021, 96: s217-s218. PMID: 34705720, DOI: 10.1097/acm.0000000000004279.Peer-Reviewed Original ResearchCIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution
Tarabra E, Nouws J, Vash‐Margita A, Hellerstein M, Shabanova V, McCollum S, Pierpont B, Zhao D, Shulman GI, Caprio S. CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution. Obesity 2021, 29: 2068-2080. PMID: 34672413, PMCID: PMC8612981, DOI: 10.1002/oby.23295.Peer-Reviewed Original ResearchConceptsAbdominal fat distributionVisceral adipose tissueCIDEA expressionFat distributionProtein levelsAbdominal SATAdolescent girlsHigher visceral adipose tissueSubcutaneous adipose tissue biopsiesAdipose tissue biopsiesReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMagnetic resonance imagingWeight gain effectsExpression of CIDEAAdipocyte dysfunctionSAT biopsiesAdipose lipidsInsulin resistanceAdipocyte hypertrophySmall adipocytesAdipose tissueTissue biopsiesUnfavorable patternsStrong inverse correlationGroup prenatal care and improved birth outcomes: Results from a type 1 hybrid effectiveness-implementation study
Lewis JB, Cunningham SD, Shabanova V, Hassan SS, Magriples U, Rodriguez MG, Ickovics JR. Group prenatal care and improved birth outcomes: Results from a type 1 hybrid effectiveness-implementation study. Preventive Medicine 2021, 153: 106853. PMID: 34678329, DOI: 10.1016/j.ypmed.2021.106853.Peer-Reviewed Original ResearchConceptsGroup prenatal carePrenatal careIndividual careBirth outcomesLower riskGroup visitsHybrid effectiveness-implementation studyHybrid effectiveness-implementation trialEffectiveness-implementation studyPrior preterm birthEffectiveness-implementation trialLow birthweight infantsHealth system savingsAbsence of randomizationPreterm birthSingleton pregnanciesPrimary outcomeWeeks' gestationGestational ageBirthweight infantsLow birthweightPotential confoundersPatientsCausal associationInverse probabilityA Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis.
Holtrop M, Heltshe S, Shabanova V, Keller A, Schumacher L, Fernandez L, Jain R. A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis. Annals Of The American Thoracic Society 2021, 18: 1158-1166. PMID: 33544657, DOI: 10.1513/annalsats.202008-1064oc.Peer-Reviewed Original ResearchConceptsLung functionSex hormonesCystic fibrosisInflammatory markersProinflammatory cytokinesHormone concentrationsEthinyl estradiol/norethindroneRegular menstrual cyclesSubset of subjectsHormone contraceptionPeak estrogenAirway inflammationPulmonary exacerbationsInflammatory biomarkersRespiratory symptomsHormonal contraceptivesHormonal contraceptionProspective studyContraceptive pillsMenstrual cycleSymptom questionnaireWorse outcomesStudy visitRespiratory pathogensClinical impactAge-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Patterns of medication use at end of life by pediatric inpatients with cancer
Prozora S, Shabanova V, Ananth P, Pashankar F, Kupfer GM, Massaro SA, Davidoff AJ. Patterns of medication use at end of life by pediatric inpatients with cancer. Pediatric Blood & Cancer 2020, 68: e28837. PMID: 33306281, DOI: 10.1002/pbc.28837.Peer-Reviewed Original ResearchConceptsMedication usePediatric inpatientsVizient Clinical Database/Resource ManagerHematopoietic stem cell transplantLife-sustaining medicationsMedication utilization patternsSymptom management medicationsUse of opioidsStem cell transplantIntensive care unitLength of stayAcademic medical centerResource use dataLast weekWarrants further studyEvidence-based approachVasopressor useEnd of lifeCare unitCell transplantMedication categoriesResuscitate statusRetrospective studyMalignancy typeOdds ratioThe association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females
Simpson S, Seifer DB, Shabanova V, Lynn AY, Howe C, Rowe E, Caprio S, Vash-Margita A. The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. Reproductive Biology And Endocrinology 2020, 18: 118. PMID: 33218348, PMCID: PMC7679991, DOI: 10.1186/s12958-020-00676-y.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeRotterdam diagnostic criteriaNon-PCOS groupMedian AMHOvarian syndromePCOS groupDiagnostic criteriaAnti-Müllerian hormone levelsAdolescent femalesRetrospective chart reviewTraditional clinical markersAnti-Müllerian hormoneCross-sectional studyWilcoxon rank sum testSignificant unadjusted differencesRank sum testD deficiencyChart reviewClinical featuresEndocrinology clinicSerum levelsAdjusted analysisUnadjusted comparisonsInsurance typeSurrogate markerA Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth
Galderisi A, Tricò D, Pierpont B, Shabanova V, Samuels S, Man C, Galuppo B, Santoro N, Caprio S. A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth. Diabetes Care 2020, 43: 2553-2563. PMID: 32788279, PMCID: PMC7510033, DOI: 10.2337/dc20-0445.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesBiomarkersEarly DiagnosisFemaleGenotypeGlucose IntoleranceGlucose Tolerance TestHumansIncretinsInsulinInsulin ResistanceInsulin SecretionInsulin-Secreting CellsMalePancreatic DiseasesPediatric ObesityPolymorphism, Single NucleotideTranscription Factor 7-Like 2 ProteinYoung AdultConceptsOral glucose tolerance testIncretin effectRs7903146 variantObese youthVariant rs7903146Obese adolescentsHyperglycemic clampInsulin sensitivityInsulin secretionC-peptide secretion rateIsoglycemic intravenous glucose infusionGlucose-induced insulin secretionImpaired glucose toleranceMetabolic phenotypeGlucose tolerance testLower insulin secretionPlasma glucose peakIntravenous glucose infusionΒ-cell functionPlasma glucose concentrationΒ-cell dysfunctionT risk alleleTranscription factor 7Wild-type genotypeIncretin responseA Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. Journal Of Nutrition 2020, 150: 2314-2321. PMID: 32652034, PMCID: PMC7467848, DOI: 10.1093/jn/nxaa183.Peer-Reviewed Original ResearchConceptsFatty liver diseasePNPLA3 rs738409 genotypeLiver diseaseAlanine aminotransferaseRs738409 genotypeInsulin sensitivityObese youthNonalcoholic fatty liver diseaseGenotype groupsWhole-body insulin sensitivityBody insulin sensitivityLinoleic acid metabolitesHepatic fat fractionMann-Whitney U testDiet imbalanceNormocaloric dietPrimary outcomeLDL cholesterolDietary interventionFatty liverUnblinded studyObese adolescentsPUFA dietMetabolic parametersStable weightFactors in Early Feeding Practices That May Influence Growth and the Challenges That Arise in Growth Outcomes Research
Fabrizio V, Shabanova V, Taylor SN. Factors in Early Feeding Practices That May Influence Growth and the Challenges That Arise in Growth Outcomes Research. Nutrients 2020, 12: 1939. PMID: 32629763, PMCID: PMC7399918, DOI: 10.3390/nu12071939.Peer-Reviewed Original ResearchConceptsWeeks gestational ageGestational agePreterm infantsEarly feeding practicesInfant growth trajectoriesFetal growth chartsSingle-center investigationInitial hospitalizationParenteral nutritionImproved outcomesInclusion criteriaFeeding practicesGrowth chartsNutritional practicesFirst weekHospital growthNutritional factorsInfantsQuartileCenter investigationLess daysOutcomes researchCaloric densityHospitalizationCohort effectsDe novo damaging variants associated with congenital heart diseases contribute to the connectome
Ji W, Ferdman D, Copel J, Scheinost D, Shabanova V, Brueckner M, Khokha MK, Ment LR. De novo damaging variants associated with congenital heart diseases contribute to the connectome. Scientific Reports 2020, 10: 7046. PMID: 32341405, PMCID: PMC7184603, DOI: 10.1038/s41598-020-63928-2.Peer-Reviewed Original ResearchMeSH KeywordsConnectomeDNA HelicasesDNA-Binding ProteinsExomeFemaleHeart Defects, CongenitalHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHumansMaleMi-2 Nucleosome Remodeling and Deacetylase ComplexMutationMutation, MissenseMyeloid-Lymphoid Leukemia ProteinNerve Tissue ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Receptor, Notch1ConceptsDe novo variantsNDD genesCardiac patterningDe novo damaging variantsDamaging de novo variantsCHD genesDamaging variantsGenesProtein truncatingGenetic originNovo variantsGene mutationsPatterningRecent studiesDendritic developmentVariantsMutationsNeurogenesisSynaptogenesisBonferroni correctionUmbilical catheter-associated complications in a level IV neonatal intensive care unit
Levit OL, Shabanova V, Bizzarro MJ. Umbilical catheter-associated complications in a level IV neonatal intensive care unit. Journal Of Perinatology 2020, 40: 573-580. PMID: 31911645, DOI: 10.1038/s41372-019-0579-3.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitIntensive care unitLevel IV neonatal intensive care unitCatheter-associated complicationsUmbilical arterial catheterUmbilical cathetersCare unitCatheter useArterial catheterArterial catheter useUmbilical venous catheterVenous catheter useObservational cohort studyCatheter dwell timeCohort studyComplication rateCumulative incidenceVenous cathetersCox regressionResultsFifty-oneComplicationsCatheterEvent ratesSignificant riskLower percentage