Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors*
Donigan KA, Sun KW, Nemec AA, Murphy DL, Cong X, Northrup V, Zelterman D, Sweasy JB. Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors*. Journal Of Biological Chemistry 2012, 287: 23830-23839. PMID: 22577134, PMCID: PMC3390656, DOI: 10.1074/jbc.m111.324947.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBinding SitesBiocatalysisCell SurvivalCells, CulturedColorectal NeoplasmsDNA Polymerase betaEmbryo, MammalianFibroblastsGenetic Complementation TestHEK293 CellsHumansKineticsMethyl MethanesulfonateMiceMice, KnockoutModels, MolecularMutagensMutationMutation RateNeoplasm StagingProtein Structure, TertiaryConceptsPolB geneGenomic instabilityEnzyme functionBase excision repair functionNonsynonymous amino acid substitutionsExcision repair functionBase excision repairEnzyme activityAmino acid substitutionsCellular transformationExcision repairRepair functionDeficient cellsSequencing studiesAcid substitutionsPol βΒ variantΒ-proteinTissue originHuman colorectal tumorsGenesRegion mutationsHuman tumorsTumorigenesisVariants