2020
A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. Journal Of Nutrition 2020, 150: 2314-2321. PMID: 32652034, PMCID: PMC7467848, DOI: 10.1093/jn/nxaa183.Peer-Reviewed Original ResearchConceptsFatty liver diseasePNPLA3 rs738409 genotypeLiver diseaseAlanine aminotransferaseRs738409 genotypeInsulin sensitivityObese youthNonalcoholic fatty liver diseaseGenotype groupsWhole-body insulin sensitivityBody insulin sensitivityLinoleic acid metabolitesHepatic fat fractionMann-Whitney U testDiet imbalanceNormocaloric dietPrimary outcomeLDL cholesterolDietary interventionFatty liverUnblinded studyObese adolescentsPUFA dietMetabolic parametersStable weight
2010
Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion
D'Adamo E, Northrup V, Weiss R, Santoro N, Pierpont B, Savoye M, O'Malley G, Caprio S. Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion. American Journal Of Clinical Nutrition 2010, 92: 500-508. PMID: 20573788, PMCID: PMC2921534, DOI: 10.3945/ajcn.2010.29270.Peer-Reviewed Original ResearchConceptsHepatic fat fractionObese adolescentsLarge HDLEthnic differencesFat accretionCardiometabolic risk factorsDeleterious metabolic effectsNormal glucose toleranceLipoprotein particle numberVisceral fat depositionLiver fat contentLarge VLDL particlesLarge HDL particlesImportance of liverMagnetic resonance imagingAfrican AmericansSuccessive tertilesMultivariate adjustmentGlucose toleranceLiver fatLower triglyceridesLipoprotein concentrationsRisk factorsLipoprotein subclassesMetabolic effects