2024
Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies.
Faustino E, Kandil S, Leroue M, Sochet A, Kong M, Cholette J, Nellis M, Pinto M, Chegondi M, Ramirez M, Schreiber H, Kerris E, Glau C, Kolmar A, Muisyo T, Sharathkumar A, Polikoff L, Silva C, Ehrlich L, Navarro O, Spinella P, Raffini L, Taylor S, McPartland T, Shabanova V. Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies. Pediatric Critical Care Medicine 2024 PMID: 39560771, DOI: 10.1097/pcc.0000000000003648.Peer-Reviewed Original ResearchRandomized clinical trialsDose of enoxaparinCatheter-relatedEarly thromboprophylaxisHigher risk of clinically relevant bleedingRisk of clinically relevant bleedingProphylactic doses of enoxaparinTherapeutic dose of enoxaparinOlder childrenMarkers of thrombin generationClinically relevant bleedingEfficacy of prophylaxisDeep venous thrombosisRemoval of CVCsCritically ill childrenPlatelet-poor plasmaPost hoc analysisGestational ageInternational unitsInstitutional review boardRelevant bleedingProphylactic doseUsual careAge-dependent heterogeneityVenous thrombosis
2021
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potential
2018
Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents
Faustino EVS, Shabanova V, Pinto MG, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Napolitano M, Brudnicki AR, Tala JA, Silva CT, Investigators T, Miksa M, Taragin B, Blickman J, Taillie E, Trakas E, Balasco A, Herliczek T, Polikoff L, Dovi G, Napolitano M, Gertz S, Riordan M, Zasa J, Brudnicki A, Eldridge P, Li S, Pinto M, Faustino E, Silva C, Tala J. Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents. The Journal Of Pediatrics 2018, 201: 176-183.e2. PMID: 29891258, DOI: 10.1016/j.jpeds.2018.05.006.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisExtremity deep venous thrombosisIll adolescentsVenous thrombosisFrequency of DVTLower extremity deep venous thrombosisCases of DVTBilateral deep venous thrombosisPediatric intensive care unitInvasive mechanical ventilationCentral venous catheterizationIntensive care unitPharmacologic prophylaxisTherapeutic anticoagulationCohort studyPulmonary embolismCardiopulmonary supportCare unitMechanical ventilationVenous catheterizationSevere illnessSerial sonogramsLower extremitiesEpidemiologyThrombosis
2016
Prediction of Catheter-Associated Thrombosis in Critically Ill Children
Marquez A, Shabanova V, Faustino EV. Prediction of Catheter-Associated Thrombosis in Critically Ill Children. Pediatric Critical Care Medicine 2016, 17: e521-e528. PMID: 27662566, DOI: 10.1097/pcc.0000000000000958.Peer-Reviewed Original ResearchConceptsCatheter-associated thrombosisCentral venous cathetersVenous cathetersIll childrenRecent surgeryHigh riskCatheter-associated deep venous thrombosisMulticenter prospective cohort studyBlood product transfusionDeep venous thrombosisProspective cohort studyCritically Ill ChildrenSeverity of illnessRisk prediction modelProduct transfusionCohort studyVenous thrombosisGroup of childrenSubclavian veinActive surveillanceThrombosisCatheterSecondary analysisLogistic regressionCharacteristic curve
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosis
2011
Survey of pharmacologic thromboprophylaxis in critically ill children*
Faustino EV, Patel S, Thiagarajan RR, Cook DJ, Northrup V, Randolph AG. Survey of pharmacologic thromboprophylaxis in critically ill children*. Critical Care Medicine 2011, 39: 1773-1778. PMID: 21423003, PMCID: PMC3118917, DOI: 10.1097/ccm.0b013e3182186ec0.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitCare unitIll childrenPharmacologic thromboprophylaxisPediatric intensive care unit patientsIntensive care unit patientsPresence of hypercoagulabilityDeep venous thrombosisCare unit patientsEvidence-based guidelinesCross-sectional self-administered surveyRigorous randomized trialsMajor bleedingLack of evidenceUnit patientsPatient factorsVenous thrombosisCavopulmonary anastomosisRandomized trialsWeight heparinPediatric intensivistsThromboprophylaxisInfant scenarioInvasive interventions“Change, before you have to.”–Jack Welch, Former CEO, General Electric*
Faustino EV, Lawson KA, Northrup V, Higgerson RA. “Change, before you have to.”–Jack Welch, Former CEO, General Electric*. Critical Care Medicine 2011, 40: 2227-2228. PMID: 21336130, PMCID: PMC3101274, DOI: 10.1097/ccm.0b013e31820eb8a1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCase-Control StudiesCatheterization, Central VenousCause of DeathChildChild, PreschoolCritical CareCritical IllnessFemaleHospital MortalityHumansInfantIntensive Care Units, PediatricMalePrognosisReference ValuesRespiration, ArtificialRetrospective StudiesRisk AssessmentSex FactorsSurvival AnalysisTime FactorsTreatment OutcomeVenous ThrombosisConceptsVentilator-free daysIntensive care unitCentral venous lineDeep venous thrombosisDeep vein thrombosisIndex patientsVenous thrombosisCare unitMechanical ventilationIll childrenControl patientsVein thrombosisVenous lineIntensive care unit-free daysIntensive care unit stayPrevious prospective observational studyPediatric intensive care unitCentral venous line insertionSymptomatic venous thromboembolismVenous thrombosis studyProspective observational studyAlternative outcome measuresUnit stayVenous thromboembolismCohort study