2022
Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ. Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results. Journal Of Neurosurgery 2022, 138: 2022.6.jns212483. PMID: 35932269, PMCID: PMC10193464, DOI: 10.3171/2022.6.jns212483.Peer-Reviewed Original ResearchMeSH KeywordsEssential TremorFollow-Up StudiesHumansMagnetic Resonance ImagingProspective StudiesQuality of LifeThalamusTreatment OutcomeTremorConceptsFunctional disability scoreAdverse eventsFocused ultrasound thalamotomyQuality of lifeDisability scoresMotor scoresUltrasound thalamotomyMagnetic resonance imaging-guided focused ultrasound thalamotomyEssential tremorMedication-refractory essential tremorNew adverse eventsCohort of patientsQUEST scoresMulticenter clinical trialClinical trial registrationEssential Tremor QuestionnaireLong-term safetyClinical rating scalesRespective time pointsTremor improvementTRIAL REGISTRATIONClinical trialsTremor scorePostural tremorLife measures
2021
Latent brain state dynamics and cognitive flexibility in older adults
Lee B, Cai W, Young CB, Yuan R, Ryman S, Kim J, Santini V, Henderson VW, Poston KL, Menon V. Latent brain state dynamics and cognitive flexibility in older adults. Progress In Neurobiology 2021, 208: 102180. PMID: 34627994, PMCID: PMC9585912, DOI: 10.1016/j.pneurobio.2021.102180.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingBayes TheoremBrainCognitionHumansMagnetic Resonance ImagingMemory, Short-TermMiddle AgedConceptsBrain flexibilityOlder adultsBrain statesWhole-brain fMRI dataBrain state dynamicsHealthy older adultsCognitive flexibilityMemory taskCognitive inflexibilityNeurocomputational frameworkCognitive deficitsFMRI dataCognitive impairmentDynamic temporal propertiesInflexibilityAdultsTemporal propertiesPublic health concernCognitionSternbergElderly populationHealth concernTaskDeficitsImpairment
2017
Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome
Federau C, Goubran M, Rosenberg J, Henderson J, Halpern CH, Santini V, Wintermark M, Pauly K, Ghanouni P. Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome. Journal Of Magnetic Resonance Imaging 2017, 48: 58-65. PMID: 29076274, DOI: 10.1002/jmri.25878.Peer-Reviewed Original ResearchConceptsMedication-refractory essential tremorClinical outcomesEssential tremorThalamic nucleiLesion volumeLesion sizeAnterior commissure-posterior commissure planeLateral posterior thalamic nucleusPilot studyFinal lesion volumePosterior thalamic nucleusPromising noninvasive methodWilcoxon twoVentral divisionPosttreatment imagesLesion locationYear posttreatmentPosterior commissureScore improvementDoseNoninvasive methodTremorJ. MagnStatistical significanceTechnical efficacyCost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor
Ravikumar VK, Parker JJ, Hornbeck TS, Santini VE, Pauly KB, Wintermark M, Ghanouni P, Stein SC, Halpern CH. Cost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor. Movement Disorders 2017, 32: 1165-1173. PMID: 28370272, DOI: 10.1002/mds.26997.Peer-Reviewed Original Research