2022
Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ. Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results. Journal Of Neurosurgery 2022, 138: 2022.6.jns212483. PMID: 35932269, PMCID: PMC10193464, DOI: 10.3171/2022.6.jns212483.Peer-Reviewed Original ResearchConceptsFunctional disability scoreAdverse eventsFocused ultrasound thalamotomyQuality of lifeDisability scoresMotor scoresUltrasound thalamotomyMagnetic resonance imaging-guided focused ultrasound thalamotomyEssential tremorMedication-refractory essential tremorNew adverse eventsCohort of patientsQUEST scoresMulticenter clinical trialClinical trial registrationEssential Tremor QuestionnaireLong-term safetyClinical rating scalesRespective time pointsTremor improvementTRIAL REGISTRATIONClinical trialsTremor scorePostural tremorLife measures
2021
Latent brain state dynamics and cognitive flexibility in older adults
Lee B, Cai W, Young CB, Yuan R, Ryman S, Kim J, Santini V, Henderson VW, Poston KL, Menon V. Latent brain state dynamics and cognitive flexibility in older adults. Progress In Neurobiology 2021, 208: 102180. PMID: 34627994, PMCID: PMC9585912, DOI: 10.1016/j.pneurobio.2021.102180.Peer-Reviewed Original ResearchConceptsBrain flexibilityOlder adultsBrain statesWhole-brain fMRI dataBrain state dynamicsHealthy older adultsCognitive flexibilityMemory taskCognitive inflexibilityNeurocomputational frameworkCognitive deficitsFMRI dataCognitive impairmentDynamic temporal propertiesInflexibilityAdultsTemporal propertiesPublic health concernCognitionSternbergElderly populationHealth concernTaskDeficitsImpairmentNeurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting
Turner BE, Magnani CJ, Frolov A, Weeks BT, Steinberg JR, Huda N, Shah LM, Zuroff L, Gu BJ, Rasmussen H, Edwards JG, Save AV, Shen M, Ren M, Bryant BR, Ma Q, Feng AY, Liang AC, Santini VE. Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting. Journal Of The Neurological Sciences 2021, 428: 117579. PMID: 34332371, DOI: 10.1016/j.jns.2021.117579.Peer-Reviewed Original ResearchConceptsEarly discontinuationClinical trialsTrial characteristicsNeurological disease burdenMultivariable logistic regressionCross-sectional analysisGovernment-funded trialsYear of completionMultivariable analysisCox regressionTreatment optionsDisease burdenHigher oddsTrial completionClinical careDiscontinuationLower riskAcademic trialsNeurology clinical trialsGreater riskLogistic regressionComparison trialEvidence baseTrialsTherapeutic focus
2020
Sacral Nerve Stimulation in Parkinson's Disease Patients With Overactive Bladder Symptoms
Greenberg DR, Sohlberg EM, Zhang CA, Santini VE, Comiter CV, Enemchukwu EA. Sacral Nerve Stimulation in Parkinson's Disease Patients With Overactive Bladder Symptoms. Urology 2020, 144: 99-105. PMID: 32681915, DOI: 10.1016/j.urology.2020.06.063.Peer-Reviewed Original ResearchConceptsSacral nerve stimulationOveractive bladder symptomsPD patientsParkinson's disease patientsDisease patientsBladder symptomsNerve stimulationHigh maximal urethral closure pressureMaximal urethral closure pressurePost-void residual volumeStage IILevodopa equivalent daily dosePD disease durationStage I trialVoids/dayStage I patientsUrethral closure pressureEquivalent daily doseMale PD patientsBody mass indexLong-term outcomesSafety of treatmentRate of progressionLatest clinicDisease durationAttracting neurology's next generation: A qualitative study of specialty choice and perceptions.
Jordan JT, Cahill C, Ostendorf T, Gutmann L, Navarro A, Gamaldo CE, Santini VE, Ali I, Soni M, Wilson RB, Said RR, Czeisler BM, Rock M, Smith AG. Attracting neurology's next generation: A qualitative study of specialty choice and perceptions. Neurology 2020, 95: e1080-e1090. PMID: 32332127, DOI: 10.1212/wnl.0000000000009461.Peer-Reviewed Original Research
2019
Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor.
Halpern CH, Santini V, Lipsman N, Lozano AM, Schwartz ML, Shah BB, Elias WJ, Cosgrove GR, Hayes MT, McDannold N, Aldrich C, Eisenberg HM, Gandhi D, Taira T, Gwinn R, Ro S, Witt J, Jung NY, Chang JW, Rosenberg J, Ghanouni P. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor. Neurology 2019, 93: e2284-e2293. PMID: 31748250, DOI: 10.1212/wnl.0000000000008561.Peer-Reviewed Original ResearchConceptsFocused ultrasound thalamotomyAdverse eventsQuality of lifeEssential tremorProspective trialUltrasound thalamotomyMedication-refractory essential tremorTcMRgFUS thalamotomyMulticenter prospective trialNew adverse eventsClass IV evidenceHand tremorEssential Tremor QuestionnaireSevere essential tremorClinical rating scalesMagnetic resonance-guided focused ultrasound thalamotomyClinical outcomesFunctional disabilityThird followTreatment metricsTremor scorePostural tremorDurable benefitThalamotomyMedian scoreCharacteristics of graduating US allopathic medical students pursuing a career in neurology.
Gutmann L, Cahill C, Jordan JT, Gamaldo CE, Santini V, Ali I, Soni M, Wilson RB, Said R, Czeisler BM, Smith AG. Characteristics of graduating US allopathic medical students pursuing a career in neurology. Neurology 2019, 92: e2051-e2063. PMID: 30926683, DOI: 10.1212/wnl.0000000000007369.Peer-Reviewed Original Research
2018
Neurology Residents as Comprehensive Educators (Neuro RACE)
Santini VE, Wu CK, Hohler AD. Neurology Residents as Comprehensive Educators (Neuro RACE). The Neurologist 2018, 23: 149-151. PMID: 30169365, DOI: 10.1097/nrl.0000000000000191.Peer-Reviewed Original ResearchConceptsSmall group discussionsNeurology residentsTeacher curriculumTeaching abilityFormal schoolingPostcurriculum surveysAcademic trainingCurriculumResident curriculumTraining programAcademic medicineGroup discussionsEducatorsNeurology training programsField of neurologyIntegral partResidents' responsesMonthly sessionsTeachingDidacticsSchoolingEducationInstructionLearningCareerSlower saccadic reading in Parkinson’s disease
Jehangir N, Yu CY, Song J, Shariati MA, Binder S, Beyer J, Santini V, Poston K, Liao YJ. Slower saccadic reading in Parkinson’s disease. PLOS ONE 2018, 13: e0191005. PMID: 29364897, PMCID: PMC5783375, DOI: 10.1371/journal.pone.0191005.Peer-Reviewed Original ResearchConceptsUnified Parkinson's Disease Rating ScaleDuration of diseasePD patientsDisease Rating ScaleParkinson's diseaseQuality of lifeConvergence insufficiencyVisual Functioning Questionnaire-25Parkinson's Disease Rating ScaleDegeneration of dopaminergicVFQ-25 scoresMontreal Cognitive Assessment (MoCA) testAbnormal eye movementsNon-motor deficitsIdiopathic Parkinson's diseaseNational Eye InstituteAge-matched controlsKing-Devick testCognitive Assessment testEye InstituteMoCA scoresPatientsControl groupClinical settingMotor difficulties
2017
Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome
Federau C, Goubran M, Rosenberg J, Henderson J, Halpern CH, Santini V, Wintermark M, Pauly K, Ghanouni P. Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome. Journal Of Magnetic Resonance Imaging 2017, 48: 58-65. PMID: 29076274, DOI: 10.1002/jmri.25878.Peer-Reviewed Original ResearchConceptsMedication-refractory essential tremorClinical outcomesEssential tremorThalamic nucleiLesion volumeLesion sizeAnterior commissure-posterior commissure planeLateral posterior thalamic nucleusPilot studyFinal lesion volumePosterior thalamic nucleusPromising noninvasive methodWilcoxon twoVentral divisionPosttreatment imagesLesion locationYear posttreatmentPosterior commissureScore improvementDoseNoninvasive methodTremorJ. MagnStatistical significanceTechnical efficacyCost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor
Ravikumar VK, Parker JJ, Hornbeck TS, Santini VE, Pauly KB, Wintermark M, Ghanouni P, Stein SC, Halpern CH. Cost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor. Movement Disorders 2017, 32: 1165-1173. PMID: 28370272, DOI: 10.1002/mds.26997.Peer-Reviewed Original Research
2016
Abnormal eye movement behavior during reading in Parkinson's disease
Yu CY, Lee T, Shariati MA, Santini V, Poston K, Liao YJ. Abnormal eye movement behavior during reading in Parkinson's disease. Parkinsonism & Related Disorders 2016, 32: 130-132. PMID: 27592009, PMCID: PMC10635678, DOI: 10.1016/j.parkreldis.2016.08.008.Peer-Reviewed Original ResearchConceptsParkinson's diseaseVisual acuityUnderstanding of PDNeuro-ophthalmic evaluationDopamine replacement therapyNeuro-ophthalmic examinationEye movement abnormalitiesGood visual acuityNormal eye movementsMotor planningKing-Devick testReplacement therapyClinical examinationMovement abnormalitiesOcular alignmentInfrared oculographySmaller saccade amplitudeVision lossEye movement behaviorNormal saccadesDiseasePatientsNormal numbersMotor abilitiesSaccade amplitude
2015
Increasing student recruitment into neurology
Larsen DP, Santini VE. Increasing student recruitment into neurology. Neurology 2015, 84: 2302-2303. PMID: 25957335, DOI: 10.1212/wnl.0000000000001668.Peer-Reviewed Original Research
2009
Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury. Journal Of Neuropathology & Experimental Neurology 2009, 68: 709-735. PMID: 19535999, PMCID: PMC2945234, DOI: 10.1097/nen.0b013e3181a9d503.Peer-Reviewed Original ResearchConceptsChronic traumatic encephalopathyTraumatic encephalopathyProgressive tauopathyTau-immunoreactive neurofibrillary tanglesRepetitive brain traumaRepetitive head injuryProgressive neurological deteriorationCavum septum pellucidumSuperficial cortical layersMedial temporal lobeAstrocytic tanglesTau-immunoreactiveNeurological deteriorationDementia pugilisticaVentricular dilatationBrain traumaHead injurySeptum pellucidumNeurofibrillary degenerationMammillary bodiesNeurofibrillary tanglesDiffuse plaquesGait abnormalitiesMemory disturbanceTemporal lobe
2008
Clock drawing performance in cognitively normal elderly
Hubbard EJ, Santini V, Blankevoort CG, Volkers KM, Barrup MS, Byerly L, Chaisson C, Jefferson AL, Kaplan E, Green RC, Stern RA. Clock drawing performance in cognitively normal elderly. Archives Of Clinical Neuropsychology 2008, 23: 295-327. PMID: 18243644, PMCID: PMC2752157, DOI: 10.1016/j.acn.2007.12.003.Peer-Reviewed Original Research