2020
Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept
Ugwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept. American Journal Of Kidney Diseases 2020, 76: 806-814.e1. PMID: 32505812, PMCID: PMC8667815, DOI: 10.1053/j.ajkd.2020.05.003.Peer-Reviewed Original ResearchConceptsAKI alertsHospitalized adultsKidney injuryUrban tertiary care hospitalAcute kidney injurySerum creatinine levelsObservational cohort studyTertiary care hospitalSerum creatinine concentrationBeats/minElectronic health recordsAKI diagnosisCohort studyCreatinine levelsInpatient mortalitySystolic bloodFractional excretionCenter studyBlood biomarkersUnivariable associationsUrine microscopyCreatinine concentrationClinical careElevated riskUrea nitrogenReal World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure A U.S. Center’s Experience
Griffin M, Soufer A, Goljo E, Colna M, Rao VS, Jeon S, Raghavendra P, D'Ambrosi J, Riello R, Coca SG, Mahoney D, Jacoby D, Ahmad T, Chen M, Tang WHW, Turner J, Mullens W, Wilson FP, Testani JM. Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure A U.S. Center’s Experience. JACC Heart Failure 2020, 8: 199-208. PMID: 32035891, PMCID: PMC7814403, DOI: 10.1016/j.jchf.2019.10.012.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureHypertonic saline administrationHypertonic saline therapyHypertonic salineSaline administrationSaline therapyDiuretic efficiencyUrine outputSerum sodiumWeight lossAcute decompensated heartDecompensated heart failureCohort of patientsTotal urine outputReal-world safetyU.S. academic medical centersAcademic medical centerLarge U.S. academic medical centerDiuretic doseCenter experienceHeart failureMetabolic derangementsPrimary analytic approachRespiratory statusClinical variables
2016
Associations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function
Parikh C, Hall I, Bhangoo R, Ficek J, Abt P, Thiessen-Philbrook H, Lin H, Bimali M, Murray P, Rao V, Schröppel B, Doshi M, Weng F, Reese P. Associations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function. American Journal Of Transplantation 2016, 16: 1526-1539. PMID: 26695524, PMCID: PMC4844819, DOI: 10.1111/ajt.13655.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsBiomarkersCadaverDelayed Graft FunctionFemaleFollow-Up StudiesHumansHypothermia, InducedKidney Failure, ChronicKidney Function TestsKidney TransplantationMaleMiddle AgedOrgan PreservationPerfusionPrognosisProspective StudiesTime FactorsTissue and Organ ProcurementTissue DonorsConceptsDelayed graft functionHypothermic machine perfusionTransplanted kidneysAllograft functionGraft functionPerfusate biomarkersDeceased donor kidney transplantationKidney allograft functionL-FABP concentrationDonor kidney transplantationHigher NGALKidney transplantationKidney qualityMachine perfusionOrgan qualityBiomarker levelsMost recipientsBiomarker concentrationsPerfusion biomarkersKidneyAdditional studiesBiomarkersEGFRRecipientsMedian resistance