2019
FGF-23 and Cardio-Renal Interactions in Heart Failure
Stewart B, Gomez N, Barnett J, Thomas A, Wycallis E, Pattoli M, Struyk G, Fleming J, Shamlian P, Raghavendra P, Mahoney D, Ivey-Miranda J, Griffin M, Rao V, Testani J. FGF-23 and Cardio-Renal Interactions in Heart Failure. Journal Of Cardiac Failure 2019, 25: s23-s24. DOI: 10.1016/j.cardfail.2019.07.545.Peer-Reviewed Original ResearchCardio-renal dysfunctionFGF-23 levelsFGF-23NT-proBNPDiuretic responsivenessIL-6Outpatient heart failure (HF) patientsPlasma FGF-23 levelsFibroblast growth factor 23Adverse left ventricular remodelingCardio-renal interactionsHigher NT-proBNPTotal renin levelsPlasma IL-6Heart failure patientsRenal sodium retentionGrowth factor 23High plasma reninLeft ventricular remodelingInduction of inflammationStrong independent associationResults Higher levelsDiuretic doseNeurohormonal activationPhosphaturic hormoneRenal Diuretic Delivery is Highly Variable in Hospitalized Decompensated Heart Failure Patients and Associated with Diuretic Resistance
Wycallis E, Stewart B, Ivey-Miranda J, Griffin M, Gomez N, Thomas A, Barnett J, Pattoli M, Struyk G, Fleming J, Shamlian P, Raghavendra P, Rao V, Cox Z, Testani J. Renal Diuretic Delivery is Highly Variable in Hospitalized Decompensated Heart Failure Patients and Associated with Diuretic Resistance. Journal Of Cardiac Failure 2019, 25: s3. DOI: 10.1016/j.cardfail.2019.07.018.Peer-Reviewed Original ResearchLoop diureticsADHF patientsTubular sitesRenal perfusionSite of actionRenal urea handlingDecompensated heart failure patientsYale-New Haven HospitalGood urine outputHospitalized ADHF patientsNT-proBNP levelsHeart failure patientsRoute of administrationNew Haven HospitalUrea handlingDiuretic doseDiuretic resistanceFurosemide equivalentsSolute handlingRenal dysfunctionBlood pressureEjection fractionFailure patientsFractional excretionUrine output
2018
The Renal Effects of Aggressive Volume Removal in Heart Failure Patients with Preexisting Worsening Renal Function
Mahoney D, Ahmad T, Rao V, Brisco-Bacik M, Wilson F, Siew E, Felker G, Anstrom K, Bart B, Tang W, O'Connor C, Velazquez E, Testani J. The Renal Effects of Aggressive Volume Removal in Heart Failure Patients with Preexisting Worsening Renal Function. Journal Of Cardiac Failure 2018, 24: s26. DOI: 10.1016/j.cardfail.2018.07.074.Peer-Reviewed Original ResearchRenal tubular injury biomarkersTubular injury biomarkersRenal tubular injuryHeart failure patientsInjury biomarkersTubular injuryFailure patientsRenal functionAcute decompensated heart failure patientsDecompensated heart failure patientsVolume removalCARRESS-HF trialRenal function recoveryTubular injury markersWorsening Renal FunctionHalf of patientsADHF patientsEffective decongestionRenal effectsInjury markersPharmacologic therapyTransient findingFunction recoveryHigh incidencePatients
2017
010 Urine Sodium Content is Highly Variable in Hospitalized Acute Heart Failure Patients: Lasix Urine is Not Necessarily “Half-Normal Saline”
Chunara Z, Jackson K, Rao V, Mahoney D, Thomas D, Tarleton C, Hodson D, Chen M, Jacoby D, Riello R, Ahmad T, Testani J. 010 Urine Sodium Content is Highly Variable in Hospitalized Acute Heart Failure Patients: Lasix Urine is Not Necessarily “Half-Normal Saline”. Journal Of Cardiac Failure 2017, 23: s7. DOI: 10.1016/j.cardfail.2017.07.013.Peer-Reviewed Original Research
2016
090 Aspirin Does Not Have a Significant Impact on Loop Diuretic Response or Renin Release in Heart Failure Patients
Broughton J, Hanberg J, Assefa M, Rao V, Testani J. 090 Aspirin Does Not Have a Significant Impact on Loop Diuretic Response or Renin Release in Heart Failure Patients. Journal Of Cardiac Failure 2016, 22: s34-s35. DOI: 10.1016/j.cardfail.2016.06.108.Peer-Reviewed Original Research029 Differential Effect of Diuretic Efficiency on Survival in Acute Heart Failure Patients with Preserved Versus Reduced Ejection Fraction
Assefa M, Hanberg J, Maaten J, Broughton J, Rao V, Testani J. 029 Differential Effect of Diuretic Efficiency on Survival in Acute Heart Failure Patients with Preserved Versus Reduced Ejection Fraction. Journal Of Cardiac Failure 2016, 22: s13. DOI: 10.1016/j.cardfail.2016.06.046.Peer-Reviewed Original ResearchRENAL TUBULAR RESISTANCE, RATHER THAN DIURETIC DELIVERY, IS THE PRIMARY DRIVER FOR DIURETIC RESISTANCE IN ACUTE HEART FAILURE PATIENTS
Maaten J, Rao V, Simon J, Assefa M, Broughton S, Modesto K, Damman K, Voors A, Tang W, Testani J. RENAL TUBULAR RESISTANCE, RATHER THAN DIURETIC DELIVERY, IS THE PRIMARY DRIVER FOR DIURETIC RESISTANCE IN ACUTE HEART FAILURE PATIENTS. Journal Of The American College Of Cardiology 2016, 67: 1544. DOI: 10.1016/s0735-1097(16)31545-5.Peer-Reviewed Original Research