2010
Genome-Wide Identification of Binding Sites Defines Distinct Functions for Caenorhabditis elegans PHA-4/FOXA in Development and Environmental Response
Zhong M, Niu W, Lu ZJ, Sarov M, Murray JI, Janette J, Raha D, Sheaffer KL, Lam HY, Preston E, Slightham C, Hillier LW, Brock T, Agarwal A, Auerbach R, Hyman AA, Gerstein M, Mango SE, Kim SK, Waterston RH, Reinke V, Snyder M. Genome-Wide Identification of Binding Sites Defines Distinct Functions for Caenorhabditis elegans PHA-4/FOXA in Development and Environmental Response. PLOS Genetics 2010, 6: e1000848. PMID: 20174564, PMCID: PMC2824807, DOI: 10.1371/journal.pgen.1000848.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCaenorhabditis elegansCaenorhabditis elegans ProteinsChromatin ImmunoprecipitationEmbryo, NonmammalianEnvironmentGene Expression Regulation, DevelopmentalGenes, HelminthGenome, HelminthGreen Fluorescent ProteinsLarvaProtein BindingRecombinant Fusion ProteinsRNA Polymerase IIStarvationSurvival AnalysisTrans-ActivatorsTranscription FactorsConceptsTranscription factorsPHA-4PHA-4/FOXADiverse biological rolesDifferent biological processesBinding sitesWide IdentificationStarvation responseCellular processesChromatin immunoprecipitationRegulatory networksOrgan developmentDistinct functionsDeep sequencingBiological roleBiological processesEmbryonic pharynxEnvironmental responsesGlobal identificationEnvironmental stimuliDistinct rolesExperimental pipelineCaenorhabditisGenesCritical role
2008
MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans
Leacock SW, Reinke V. MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans. Genetics 2008, 178: 295-306. PMID: 18202375, PMCID: PMC2206079, DOI: 10.1534/genetics.107.080218.Peer-Reviewed Original ResearchConceptsP granulesMeg 1Germline developmentGerm lineageMEG 2Embryonic germ lineagesP-granule componentEmbryonic cell divisionGerm cell proliferationGLH-1Germ granulesSomatic lineagesCaenorhabditis elegansGermline segregationMis-segregationMaternal germlineCell divisionGerm cellsPhenotype increasesLineagesGermline defectsPGL-1MutantsProliferationGranules
2002
X-chromosome silencing in the germline of C. elegans.
Kelly WG, Schaner CE, Dernburg AF, Lee MH, Kim SK, Villeneuve AM, Reinke V. X-chromosome silencing in the germline of C. elegans. Development 2002, 129: 479-92. PMID: 11807039, PMCID: PMC4066729, DOI: 10.1242/dev.129.2.479.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansDisorders of Sex DevelopmentFemaleGene Expression Regulation, DevelopmentalGene SilencingGenes, ReporterGerm CellsGonadsHistonesImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMeiosisMethylationOligonucleotide Array Sequence AnalysisOocytesRecombinant Fusion ProteinsSpermatozoaTranscription, GeneticTransgenesX ChromosomeConceptsX chromosomeHistone modificationsC. elegansEarly meiosisX chromosome silencingNematode C. elegansGermline maintenanceNematode phylumHermaphroditic speciesChromatin organizationSex bodyXO malesTranscriptional competenceSex chromosomesTranscriptional activationTransgene arrayOocyte meiosisMeiosisChromosomesRepressive mechanismsElegansSpeciesHeterochromatinHermaphroditesGenome