2016
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea
Jafari B, Mohsenin V. Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea. Sleep Medicine 2016, 25: 87-92. PMID: 27823723, DOI: 10.1016/j.sleep.2016.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersChitinase-3-Like Protein 1Endothelium, VascularFemaleHumansHypertensionMaleMiddle AgedNitric OxidePolysomnographyRisk FactorsSleep Apnea, ObstructiveVasodilationConceptsHypertensive OSAObstructive sleep apneaFlow-mediated vasodilationEndothelial dysfunctionYKL-40Sleep apneaEndothelial-dependent vasodilatory capacityNormotensive OSAChitinase-3-like protein 1Sleep-disordered breathingCharacteristic curve analysisChitinase-3-like proteinHypertension independentVasodilatory capacityCardiovascular morbidityEndothelial functionHypertension statusRisk factorsPrevalent disorderHypertensionNegative correlationDysfunctionPotential biomarkersSignificant negative correlationCurve analysis
2014
Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea
Jafari B, Elias JA, Mohsenin V. Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea. PLOS ONE 2014, 9: e98629. PMID: 24878721, PMCID: PMC4039537, DOI: 10.1371/journal.pone.0098629.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaFlow-mediated vasodilationVascular endothelial growth factorYKL-40/chitinaseApnea-hypopnea indexPlasma YKL-40YKL-40Endothelial dysfunctionVasodilatory capacitySleep apneaEndothelial-dependent vasodilatory capacityHypertensive OSANormotensive OSAApparent cardiovascular diseaseRisk of hypertensionProtein 1Events/hrEndothelial growth factorN-OSAVEGF receptor 1Oxygen desaturationSFlt-1Cardiovascular diseaseCommon disorderPositive correlation