1996
Adaptation of Lung Antioxidants to Cigarette Smoking in Humans
Hilbert J, Mohsenin V. Adaptation of Lung Antioxidants to Cigarette Smoking in Humans. CHEST Journal 1996, 110: 916-920. PMID: 8874245, DOI: 10.1378/chest.110.4.916.Peer-Reviewed Original ResearchConceptsLung lavage cellsBeta-carotene levelsVitamin EBAL cellsLavage cellsMicronutrient antioxidantsSuperoxide dismutaseGPx activityAntioxidant enzyme activitiesWeeks of supplementationBeta-carotene concentrationsGlutathione peroxidase activityIntracellular superoxide dismutaseFree radical scavengerSerum levelsCigarette smokersCigarette smokingControl subjectsBronchoalveolar cellsLung antioxidantsSmokersNonsmokersConcentration of vitaminSOD activityEnzyme activity
1991
Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses
Mohsenin V. Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses. Journal Of Applied Physiology 1991, 70: 1456-1462. PMID: 2055821, DOI: 10.1152/jappl.1991.70.4.1456.Peer-Reviewed Original ResearchConceptsElastase inhibitory capacityAlveolar lining fluidLipid peroxidation productsLining fluidLavage fluidVitamin-supplemented groupOxidant stressLipid peroxidationPeroxidation productsControl groupLower respiratory tract fluidFour-week supplementationVitamin CRespiratory tract fluidNO2 exposureInactivation of alphaConjugated dienesVitamin supplementationNormal subjectsAntielastase activityInhibitory capacityOxidant exposureSignificant decreaseAntioxidant defensePeroxidation