1996
Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils
Ortmeyer J, Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sciences 1996, 59: 255-262. PMID: 8699936, DOI: 10.1016/0024-3205(96)00284-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiabetes MellitusDose-Response Relationship, DrugGlucoseHumansNeutrophilsPhospholipase DSuperoxidesConceptsDiabetic neutrophilsSuperoxide generationInsulin-dependent diabeticsGlucose concentrationNormal glucose concentrationN-formyl-MetNeutrophil dysfunctionPhospholipase DHigh glucose concentrationsImpaired activationDiabeticsNeutrophilsLeu-PheMembrane phosphatidylcholineActivationDiabetesDysfunctionInfectionFMLPPhosphatidic acidResponse
1993
Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation
Ortmeyer J, Mohsenin V. Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation. American Journal Of Physiology 1993, 264: c402-c410. PMID: 8383432, DOI: 10.1152/ajpcell.1993.264.2.c402.Peer-Reviewed Original ResearchConceptsNormal neutrophilsActivation of PLDNADPH oxidaseTreatment of neutrophilsReceptor-mediated stimulationN-formyl-MetPLD activationDiabetic subjectsFormation of inositolReceptor stimulationPhosphoinositide hydrolysisGlucose suppressesIntracellular Ca2NeutrophilsPhospholipase D activationMarked inhibitionLeu-PhePhospholipase D activityGeneration of O2D activationNonmetabolizable sugarPhosphatidic acidSuperoxide anionActivationGlucose