1996
Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils
Ortmeyer J, Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sciences 1996, 59: 255-262. PMID: 8699936, DOI: 10.1016/0024-3205(96)00284-6.Peer-Reviewed Original ResearchConceptsDiabetic neutrophilsSuperoxide generationInsulin-dependent diabeticsGlucose concentrationNormal glucose concentrationN-formyl-MetNeutrophil dysfunctionPhospholipase DHigh glucose concentrationsImpaired activationDiabeticsNeutrophilsLeu-PheMembrane phosphatidylcholineActivationDiabetesDysfunctionInfectionFMLPPhosphatidic acidResponse
1994
Inhibition of protein kinase C of human neutrophils by phosphatidylcholines
Yoshida K, Mohsenin V. Inhibition of protein kinase C of human neutrophils by phosphatidylcholines. Life Sciences 1994, 54: 515-524. PMID: 8107528, DOI: 10.1016/0024-3205(94)90001-9.Peer-Reviewed Original ResearchConceptsEffect of phosphatidylcholineProtein kinase CActivation of neutrophilsIntact neutrophilsMechanism of actionPKC activityPulmonary surfactant phospholipidsNeutrophil activationActivation of PKCKinase CNeutrophilsIntact restingTranslocation of PKCHuman neutrophilsSurfactant phospholipidsCytosolic PKC activityDistribution of PKCSuperoxide generationControl cellsPulmonary surfactantSpecific phosphatidylcholinesStimulationActivationFatty acyl moietiesInhibition